CIAO1_CANDC
ID CIAO1_CANDC Reviewed; 380 AA.
AC B9WHJ2;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=CD36_52510;
OS Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS NRRL Y-17841) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=573826;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX PubMed=19745113; DOI=10.1101/gr.097501.109;
RA Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT Candida albicans.";
RL Genome Res. 19:2231-2244(2009).
CC -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC protein assembly machinery. Required for the maturation of
CC extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; FM992692; CAX41634.1; -; Genomic_DNA.
DR RefSeq; XP_002420555.1; XM_002420510.1.
DR AlphaFoldDB; B9WHJ2; -.
DR SMR; B9WHJ2; -.
DR STRING; 42374.XP_002420555.1; -.
DR EnsemblFungi; CAX41634; CAX41634; CD36_52510.
DR GeneID; 8048431; -.
DR KEGG; cdu:CD36_52510; -.
DR CGD; CAL0000168133; Cd36_52510.
DR VEuPathDB; FungiDB:CD36_52510; -.
DR eggNOG; KOG0645; Eukaryota.
DR HOGENOM; CLU_000288_57_8_1; -.
DR OrthoDB; 793298at2759; -.
DR Proteomes; UP000002605; Chromosome 5.
DR GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19920; PTHR19920; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Repeat; WD repeat.
FT CHAIN 1..380
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein 1"
FT /id="PRO_0000382509"
FT REPEAT 10..49
FT /note="WD 1"
FT REPEAT 56..108
FT /note="WD 2"
FT REPEAT 135..175
FT /note="WD 3"
FT REPEAT 182..221
FT /note="WD 4"
FT REPEAT 228..275
FT /note="WD 5"
FT REPEAT 299..338
FT /note="WD 6"
FT REPEAT 346..380
FT /note="WD 7"
SQ SEQUENCE 380 AA; 42381 MW; E7BBF218D612C91F CRC64;
MVELLHSIKA HNDKAWSVSV HPTLPIIATA STDKSTKLYK LSTKQKFPLV AELEDTHKRS
IRSVAFKPPL GGVDAPKLDF LDLPALAAGS FDSTISVWGI DEPDVEYDID EVVANQKEIL
TSPNNEWNLM AIIEGHENEV KAVDWNFQGQ YLASCSRDKT VWIWETDPET LEEFECVAVL
NDHSQDVKNV SWHPSMNILA SSSYDDTIRI YQQDIAGDEW SCVGILNGHE GTVWCSKFES
FKSPTADSSI LRLVSASDDL SVRIWVAKRE EEEDKPELPS SIKHTKEMVW EVESVLPAVH
KYPVYSVAWS SLTGKIASAG SDGKIVVYSE AEKGKWVIDS VHEGSHGVHE INCVIWAQLD
DENEILVSAG DDGYVNLWNV