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CIAO1_CANDC
ID   CIAO1_CANDC             Reviewed;         380 AA.
AC   B9WHJ2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=CD36_52510;
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; FM992692; CAX41634.1; -; Genomic_DNA.
DR   RefSeq; XP_002420555.1; XM_002420510.1.
DR   AlphaFoldDB; B9WHJ2; -.
DR   SMR; B9WHJ2; -.
DR   STRING; 42374.XP_002420555.1; -.
DR   EnsemblFungi; CAX41634; CAX41634; CD36_52510.
DR   GeneID; 8048431; -.
DR   KEGG; cdu:CD36_52510; -.
DR   CGD; CAL0000168133; Cd36_52510.
DR   VEuPathDB; FungiDB:CD36_52510; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000002605; Chromosome 5.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Repeat; WD repeat.
FT   CHAIN           1..380
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382509"
FT   REPEAT          10..49
FT                   /note="WD 1"
FT   REPEAT          56..108
FT                   /note="WD 2"
FT   REPEAT          135..175
FT                   /note="WD 3"
FT   REPEAT          182..221
FT                   /note="WD 4"
FT   REPEAT          228..275
FT                   /note="WD 5"
FT   REPEAT          299..338
FT                   /note="WD 6"
FT   REPEAT          346..380
FT                   /note="WD 7"
SQ   SEQUENCE   380 AA;  42381 MW;  E7BBF218D612C91F CRC64;
     MVELLHSIKA HNDKAWSVSV HPTLPIIATA STDKSTKLYK LSTKQKFPLV AELEDTHKRS
     IRSVAFKPPL GGVDAPKLDF LDLPALAAGS FDSTISVWGI DEPDVEYDID EVVANQKEIL
     TSPNNEWNLM AIIEGHENEV KAVDWNFQGQ YLASCSRDKT VWIWETDPET LEEFECVAVL
     NDHSQDVKNV SWHPSMNILA SSSYDDTIRI YQQDIAGDEW SCVGILNGHE GTVWCSKFES
     FKSPTADSSI LRLVSASDDL SVRIWVAKRE EEEDKPELPS SIKHTKEMVW EVESVLPAVH
     KYPVYSVAWS SLTGKIASAG SDGKIVVYSE AEKGKWVIDS VHEGSHGVHE INCVIWAQLD
     DENEILVSAG DDGYVNLWNV
 
 
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