ID   CIAO1_COCIM             Reviewed;         473 AA.
AC   Q1DR81; J3K3L2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=CIMG_07182;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; GG704912; EAS31703.3; -; Genomic_DNA.
DR   RefSeq; XP_001243286.1; XM_001243285.2.
DR   AlphaFoldDB; Q1DR81; -.
DR   SMR; Q1DR81; -.
DR   STRING; 246410.Q1DR81; -.
DR   EnsemblFungi; EAS31703; EAS31703; CIMG_07182.
DR   GeneID; 4561388; -.
DR   KEGG; cim:CIMG_07182; -.
DR   VEuPathDB; FungiDB:CIMG_07182; -.
DR   InParanoid; Q1DR81; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 2.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..473
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382512"
FT   REPEAT          11..58
FT                   /note="WD 1"
FT   REPEAT          62..104
FT                   /note="WD 2"
FT   REPEAT          144..183
FT                   /note="WD 3"
FT   REPEAT          191..230
FT                   /note="WD 4"
FT   REPEAT          235..313
FT                   /note="WD 5"
FT   REPEAT          341..380
FT                   /note="WD 6"
FT   REPEAT          438..473
FT                   /note="WD 7"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..397
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  52568 MW;  FE5B2D0038ED32DE CRC64;
     MPSSTPGGSL KHLSDLTPPS QDRTWLTSSH PRLPIAATCC ADKSVRVYSL VNFTLLSTIS
     GGHKRSVRSC AWKPHVKGES VLATASFDAT VGVWRRWDGF GRAERDMLGL AGGLAEADRQ
     EGDDTDGDEE DEDEEWGFAV LLDGHDSEVK SVSWSSGGSL LATCSRDKSI WIWEDLEDGD
     NNFETVAVLQ EHSGDVKWVA WHPEEECLAS GSYDDTIRLW REDVDDWGQV ACLRGHEGTV
     WCVEWEAPTS IAGDNGDGAP TTMPIDPENG KLAPCERKKW IEERSMSGPR LVSCSDDKTI
     RIWRKQPQEK PPPVQYSSIP STIRPATIDE TWIEECQLPA MHDLSIYSVA WSKKTGLIAS
     TGADGRIVIY QERFTSKPPV HTTSEQDKPD SARETQKANG ERTAPSTAWE VVACVDAAHE
     IYEVNHVCWA KRADQRKSQQ QNFDNSEMDH ANEEEVLLST GDDGVVRVWT LER