CIAO1_CRYNB
ID CIAO1_CRYNB Reviewed; 440 AA.
AC P0CS31; Q55LG3; Q5KA32;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; OrderedLocusNames=CNBJ0220;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC protein assembly machinery. Required for the maturation of
CC extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; AAEY01000048; EAL18596.1; -; Genomic_DNA.
DR RefSeq; XP_773243.1; XM_768150.1.
DR AlphaFoldDB; P0CS31; -.
DR SMR; P0CS31; -.
DR EnsemblFungi; AAW45887; AAW45887; CNJ03240.
DR EnsemblFungi; EAL18596; EAL18596; CNBJ0220.
DR GeneID; 4938353; -.
DR KEGG; cnb:CNBJ0220; -.
DR VEuPathDB; FungiDB:CNBJ0220; -.
DR HOGENOM; CLU_000288_57_8_1; -.
DR Proteomes; UP000001435; Chromosome 10.
DR GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 2.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19920; PTHR19920; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Repeat; WD repeat.
FT CHAIN 1..440
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein 1"
FT /id="PRO_0000410328"
FT REPEAT 12..51
FT /note="WD 1"
FT REPEAT 71..110
FT /note="WD 2"
FT REPEAT 148..187
FT /note="WD 3"
FT REPEAT 193..233
FT /note="WD 4"
FT REPEAT 278..317
FT /note="WD 5"
FT REPEAT 326..379
FT /note="WD 6"
FT REPEAT 401..440
FT /note="WD 7"
FT REGION 107..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 47874 MW; 6E102A0A9E6AA9C0 CRC64;
MLRLQSLGSL PAHAEPAWTV SFNPTRSLLA SCSTDRTIRL YSYIIPSSSD GLPSQDDSQA
VFSLAKVIET DHKRTVRSIA WSPDGRTLAS GSFDSTVGVW EEVIPLSDDE EEEDEGAQGV
YKPAGVDSDG DGDGGKEKEW ECVTTLEGHE SECKSVGFSS DGALLASCSR DKSVWVWEVQ
PDADFECIAV MMEHSQDVKS IAWHPHEEIL ASASYDSYIH LAYDDPDSDW CIFQKLHPSL
PSTPLTIPST SPSHLIDALV PTEEEKKAEA ELQVPPLEED ETVWCLAWSP DGRWLASGGD
NGGIRLWQRT GSQPDSAFKE ILHTAAHSRS VFSLSWSPPY PSAESAGSTD STDLGMLASA
GEDGKIIIWQ ITVPPSPSSA SQEIDNEQIS IRPIAAQKDA HGVNDINSVA WCVREDKKGW
GMLSSAGDDG SVKVWRVVRD