ID   CIAO1_CRYNJ             Reviewed;         440 AA.
AC   P0CS30; Q55LG3; Q5KA32;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; OrderedLocusNames=CNJ03240;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AE017350; AAW45887.1; -; Genomic_DNA.
DR   RefSeq; XP_567404.1; XM_567404.1.
DR   AlphaFoldDB; P0CS30; -.
DR   SMR; P0CS30; -.
DR   STRING; 5207.AAW45887; -.
DR   PaxDb; P0CS30; -.
DR   EnsemblFungi; AAW45887; AAW45887; CNJ03240.
DR   GeneID; 3254321; -.
DR   KEGG; cne:CNJ03240; -.
DR   VEuPathDB; FungiDB:CNJ03240; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; P0CS30; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000002149; Chromosome 10.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..440
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382513"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          71..110
FT                   /note="WD 2"
FT   REPEAT          148..187
FT                   /note="WD 3"
FT   REPEAT          193..233
FT                   /note="WD 4"
FT   REPEAT          278..317
FT                   /note="WD 5"
FT   REPEAT          326..379
FT                   /note="WD 6"
FT   REPEAT          401..440
FT                   /note="WD 7"
FT   REGION          107..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  47874 MW;  6E102A0A9E6AA9C0 CRC64;
     MLRLQSLGSL PAHAEPAWTV SFNPTRSLLA SCSTDRTIRL YSYIIPSSSD GLPSQDDSQA
     VFSLAKVIET DHKRTVRSIA WSPDGRTLAS GSFDSTVGVW EEVIPLSDDE EEEDEGAQGV
     YKPAGVDSDG DGDGGKEKEW ECVTTLEGHE SECKSVGFSS DGALLASCSR DKSVWVWEVQ
     PDADFECIAV MMEHSQDVKS IAWHPHEEIL ASASYDSYIH LAYDDPDSDW CIFQKLHPSL
     PSTPLTIPST SPSHLIDALV PTEEEKKAEA ELQVPPLEED ETVWCLAWSP DGRWLASGGD
     NGGIRLWQRT GSQPDSAFKE ILHTAAHSRS VFSLSWSPPY PSAESAGSTD STDLGMLASA
     GEDGKIIIWQ ITVPPSPSSA SQEIDNEQIS IRPIAAQKDA HGVNDINSVA WCVREDKKGW
     GMLSSAGDDG SVKVWRVVRD