CIAO1_DANRE
ID CIAO1_DANRE Reviewed; 330 AA.
AC Q6P0D9; B0S611; Q803C8;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
DE AltName: Full=WD repeat-containing protein 39 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=ciao1; Synonyms=wdr39; ORFNames=si:dkey-49H9.1, zgc:55911, zgc:77394;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB; TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into extramitochondrial Fe/S proteins.
CC {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SUBUNIT: Component of the CIA complex. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; BX323451; CAQ13300.1; -; Genomic_DNA.
DR EMBL; BC044534; AAH44534.1; -; mRNA.
DR EMBL; BC065658; AAH65658.1; -; mRNA.
DR EMBL; BC171538; AAI71538.1; -; mRNA.
DR EMBL; BC171540; AAI71540.1; -; mRNA.
DR RefSeq; NP_956441.2; NM_200147.2.
DR AlphaFoldDB; Q6P0D9; -.
DR SMR; Q6P0D9; -.
DR STRING; 7955.ENSDARP00000076693; -.
DR PaxDb; Q6P0D9; -.
DR Ensembl; ENSDART00000082256; ENSDARP00000076693; ENSDARG00000059212.
DR GeneID; 795104; -.
DR KEGG; dre:795104; -.
DR CTD; 9391; -.
DR ZFIN; ZDB-GENE-040426-839; ciao1.
DR eggNOG; KOG0645; Eukaryota.
DR GeneTree; ENSGT00940000158670; -.
DR HOGENOM; CLU_000288_57_8_1; -.
DR InParanoid; Q6P0D9; -.
DR OMA; AIWSKSS; -.
DR OrthoDB; 793298at2759; -.
DR PhylomeDB; Q6P0D9; -.
DR TreeFam; TF318181; -.
DR PRO; PR:Q6P0D9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000059212; Expressed in spleen and 27 other tissues.
DR GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19920; PTHR19920; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..330
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein ciao1"
FT /id="PRO_0000281108"
FT REPEAT 14..53
FT /note="WD 1"
FT REPEAT 59..98
FT /note="WD 2"
FT REPEAT 103..142
FT /note="WD 3"
FT REPEAT 148..187
FT /note="WD 4"
FT REPEAT 192..231
FT /note="WD 5"
FT REPEAT 244..283
FT /note="WD 6"
FT REPEAT 295..330
FT /note="WD 7"
FT CONFLICT 181
FT /note="D -> G (in Ref. 2; AAH44534)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="V -> M (in Ref. 2; AAH44534)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36803 MW; 63232ADD0D153162 CRC64;
MKGALELQHR VSAHPDSRCW YVAWNPAGTT LATCGGDRAI RIWGKEGDSW ECKCVLSDGH
QRTVRKVAWS PCGKYLASAS FDATTCIWKK TDEDFECLTV LEGHENEVKC VAWAPSGSLL
ATCSRDKSVW IWEVDEEDEY ECLSVVNSHT QDVKHVVWHP TQELLASASY DNKICIYKEE
DDDWECRATL EGHESTVWSL TFDPEGRRLA SCSDDRTVKI WKESTTGDGS SDESWKCICT
LSGFHGRTIY DIAWCRLTGA LATACGDDGV RVFSEDPTAD PEQPIFALSA HVPKAHNQDV
NCVSWNPKEA GLLATCSDNG EFAIWKYNSA