ID   CIAO1_DEBHA             Reviewed;         394 AA.
AC   Q6BIR9;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   OrderedLocusNames=DEHA2G08140g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CR382139; CAG90365.1; -; Genomic_DNA.
DR   RefSeq; XP_461902.1; XM_461902.1.
DR   AlphaFoldDB; Q6BIR9; -.
DR   SMR; Q6BIR9; -.
DR   STRING; 4959.XP_461902.1; -.
DR   EnsemblFungi; CAG90365; CAG90365; DEHA2G08140g.
DR   GeneID; 2904783; -.
DR   KEGG; dha:DEHA2G08140g; -.
DR   VEuPathDB; FungiDB:DEHA2G08140g; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q6BIR9; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..394
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382514"
FT   REPEAT          10..49
FT                   /note="WD 1"
FT   REPEAT          56..108
FT                   /note="WD 2"
FT   REPEAT          144..184
FT                   /note="WD 3"
FT   REPEAT          191..230
FT                   /note="WD 4"
FT   REPEAT          237..284
FT                   /note="WD 5"
FT   REPEAT          313..352
FT                   /note="WD 6"
FT   REPEAT          359..394
FT                   /note="WD 7"
SQ   SEQUENCE   394 AA;  44182 MW;  1459873DEF393BF4 CRC64;
     MVKLIKSIKA HNDKAWCAKS HPTLPLLATA STDRTSHIYN LSAKKNFPLL AKLEEAHKRS
     VRSVDFKPPL GGVESPVDDF LDLPALATGS FDSTISIWGI DEPEEQDSMD DGDDDDDDEK
     INDKHAQLLT SINNEWNLMA IIEGHENEVK SVAWNYQGNL LASCSRDKTI WIWETDPETL
     EEFECISVLS DHQHDVKHIT WHPSQNLLAS SSYDDTIKLY KQDEDDDDWS CVGILNGHGG
     TVWCSSFENP TSPTFDANKI RLVSASDDLS VRIWSSIVEQ TEQIEDTTDR LPSSIKSTNN
     EMVWEEEAIL PAIHKYAVYS VSWSAKTGKI SSTGSDGKLV IYRETESKKW EIESVYESAH
     GVYEINSVSW CTLDDKTEVL VTAGDDGAIN IWEP