ID   CIAO1_DICDI             Reviewed;         333 AA.
AC   Q55DA2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=ciao1; ORFNames=DDB_G0269728;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AAFI02000005; EAL72214.1; -; Genomic_DNA.
DR   RefSeq; XP_646229.1; XM_641137.1.
DR   AlphaFoldDB; Q55DA2; -.
DR   SMR; Q55DA2; -.
DR   STRING; 44689.DDB0266672; -.
DR   PaxDb; Q55DA2; -.
DR   EnsemblProtists; EAL72214; EAL72214; DDB_G0269728.
DR   GeneID; 8617183; -.
DR   KEGG; ddi:DDB_G0269728; -.
DR   dictyBase; DDB_G0269728; ciao1.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q55DA2; -.
DR   OMA; AIWSKSS; -.
DR   PhylomeDB; Q55DA2; -.
DR   PRO; PR:Q55DA2; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..333
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein CIAO1 homolog"
FT                   /id="PRO_0000330842"
FT   REPEAT          22..61
FT                   /note="WD 1"
FT   REPEAT          67..106
FT                   /note="WD 2"
FT   REPEAT          113..152
FT                   /note="WD 3"
FT   REPEAT          158..197
FT                   /note="WD 4"
FT   REPEAT          202..241
FT                   /note="WD 5"
FT   REPEAT          249..288
FT                   /note="WD 6"
FT   REPEAT          298..333
FT                   /note="WD 7"
SQ   SEQUENCE   333 AA;  38366 MW;  9D617399511E2635 CRC64;
     MTDTTKNDKY NLKLIDSMQK EAPYDKVWNL AWHPNGEILA TCANDKYIQI WSKDTNGKWG
     LVQSLEGHEK TVRRVAWSPC GRFLAGASFD ASTSIWEKSK DELEFTHVSS LEGHTYEVKS
     VAWDSTGTLL ATCSRDKSIW IWQMEDDNDF ECLSINSGHG QDIKCVLWHP NEELLASSSY
     DDTIKFWKDI DGDWECINTL TGHESSIWDL AFNKDGDKLV SCGEDKLVLF WKFDKENEKW
     INIFKFKNEN SRPIYSIDWS SLTNTIVTGS ADDSIIFYEQ ESDDTPDKYK IILKKKNAHD
     SDVNCTKWNP KFKNILASCG DDGFIKIWEL QDK