ID   CIAO1_DROGR             Reviewed;         331 AA.
AC   B4JW81;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=GH22988;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CH916375; EDV98219.1; -; Genomic_DNA.
DR   RefSeq; XP_001995147.1; XM_001995111.1.
DR   AlphaFoldDB; B4JW81; -.
DR   SMR; B4JW81; -.
DR   STRING; 7222.FBpp0156894; -.
DR   EnsemblMetazoa; FBtr0158402; FBpp0156894; FBgn0130445.
DR   GeneID; 6569131; -.
DR   KEGG; dgr:6569131; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; B4JW81; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; B4JW81; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..331
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein Ciao1"
FT                   /id="PRO_0000382485"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          57..96
FT                   /note="WD 2"
FT   REPEAT          97..136
FT                   /note="WD 3"
FT   REPEAT          142..181
FT                   /note="WD 4"
FT   REPEAT          188..227
FT                   /note="WD 5"
FT   REPEAT          246..285
FT                   /note="WD 6"
FT   REPEAT          297..331
FT                   /note="WD 7"
SQ   SEQUENCE   331 AA;  36648 MW;  17515818A161CEC1 CRC64;
     MGRLILEHTL QGHKGRIWGV AWHPKGNSFA SCGEDKAIRI WSQSGNTWTT KTILSDGHKR
     TIREVRWSPC GEYLASASFD ATTAIWSKHE CNATLEGHEN EVKSVSWSQS GGLLATCSRD
     KSVWIWEVAG DDEFECAAVL NAHTQDVKRV VWHPSKEILA SASYDNTIKM YAESALDSDW
     DCTATLSSHT STVWSIDFEA DGERLVSCSD DTTLKIWRAY HPGNEAGIAT PDKTTVWKCV
     CTVAGQHSRA VYDVSWCKLT GLIASACGDD GIRIFKESSD SKRDEPTFEL LTAEESAHEQ
     DVNAVEWNPV TAGQLISCSD DGTIKIWKLQ E