ID   CIAO1_DROSE             Reviewed;         335 AA.
AC   B4HRQ6;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=GM20174;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CH480816; EDW47920.1; -; Genomic_DNA.
DR   RefSeq; XP_002033907.1; XM_002033871.1.
DR   AlphaFoldDB; B4HRQ6; -.
DR   SMR; B4HRQ6; -.
DR   STRING; 7238.B4HRQ6; -.
DR   EnsemblMetazoa; FBtr0203159; FBpp0201651; FBgn0175057.
DR   GeneID; 6609216; -.
DR   KEGG; dse:6609216; -.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   OMA; AIWSKSS; -.
DR   PhylomeDB; B4HRQ6; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..335
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein Ciao1"
FT                   /id="PRO_0000382490"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          57..96
FT                   /note="WD 2"
FT   REPEAT          101..140
FT                   /note="WD 3"
FT   REPEAT          146..185
FT                   /note="WD 4"
FT   REPEAT          192..231
FT                   /note="WD 5"
FT   REPEAT          250..289
FT                   /note="WD 6"
FT   REPEAT          301..335
FT                   /note="WD 7"
SQ   SEQUENCE   335 AA;  37014 MW;  7BE45D72CD85147F CRC64;
     MGRLILEHTL QGHKGRIWGV AWHPKGNVFA SCGEDKAIRI WSLTGNTWGT KTILSDGHKR
     TIREIRWSPC GQYLASASFD ATTAIWSKSS GEFECNATLE GHENEVKSVS WSRSGGLLAT
     CSRDKSVWIW EVAGDDEFEC AAVLNPHTQD VKRVVWHPTK DVLASASYDN TIKMFAEEPI
     DNDWDCTATL TSHTSTVWGI DFDADGERLV SCSDDTTIKI WRAYHPGNTA GVATPEQQTV
     WKCVCTVSGQ HSRAIYDVSW CKLTGLIATA CGDDGIRIFK ETSDSKPDEP TFEQITAEEG
     AHDQDVNSVQ WNPVVAGQLI SCSDDGTIKI WKVSE