ID   CIAO1_DROYA             Reviewed;         335 AA.
AC   B4P7Q3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=GE12280;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CM000158; EDW91079.1; -; Genomic_DNA.
DR   RefSeq; XP_002091367.1; XM_002091331.2.
DR   AlphaFoldDB; B4P7Q3; -.
DR   SMR; B4P7Q3; -.
DR   STRING; 7245.FBpp0257290; -.
DR   EnsemblMetazoa; FBtr0258798; FBpp0257290; FBgn0230036.
DR   GeneID; 6530451; -.
DR   KEGG; dya:Dyak_GE12280; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; B4P7Q3; -.
DR   Proteomes; UP000002282; Chromosome 2R.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Repeat; WD repeat.
FT   CHAIN           1..335
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein Ciao1"
FT                   /id="PRO_0000382494"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          57..96
FT                   /note="WD 2"
FT   REPEAT          101..140
FT                   /note="WD 3"
FT   REPEAT          146..185
FT                   /note="WD 4"
FT   REPEAT          192..231
FT                   /note="WD 5"
FT   REPEAT          250..289
FT                   /note="WD 6"
FT   REPEAT          301..335
FT                   /note="WD 7"
SQ   SEQUENCE   335 AA;  37080 MW;  D35497C0A2D36109 CRC64;
     MGRLILEHTL QGHKGRIWGV AWHPKGNVFA SCGEDKAIRI WSLTGNTWST KTILSDGHKR
     TIREIQWSPC GQYLASASFD ATTAIWSKSS GEFECNATLE GHENEVKSVS WSRSGGLLAT
     CSRDKSVWIW EVAGDDEFEC AAVLNSHTQD VKRVVWHPTK EILASASYDN TIKMYAEEPI
     DNDWDCTATL TSHTSTIWGI DFDADGERLV SCSDDTTVKI WRAYHPGNSA GVATPDQQTV
     WKCVCTLSGQ HSRAIYDVSW CKLTGLIATA CGDDGIRIFK ETSDSKPDEP TFEQLTAEES
     AHDQDVNSVQ WNPVVAGQLI SCSDDGTIKI WKVTE