ID   CIAO1_IXOSC             Reviewed;         315 AA.
AC   B7QKS1;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog {ECO:0000255|HAMAP-Rule:MF_03037};
GN   ORFNames=ISCW023049;
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel;
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; DS961804; EEC19443.1; -; Genomic_DNA.
DR   RefSeq; XP_002415776.1; XM_002415731.1.
DR   AlphaFoldDB; B7QKS1; -.
DR   SMR; B7QKS1; -.
DR   STRING; 6945.B7QKS1; -.
DR   GeneID; 8042725; -.
DR   KEGG; isc:IscW_ISCW023049; -.
DR   VEuPathDB; VectorBase:ISCI023049; -.
DR   VEuPathDB; VectorBase:ISCW023049; -.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; B7QKS1; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; B7QKS1; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..315
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein CIAO1 homolog"
FT                   /id="PRO_0000382495"
FT   REPEAT          11..50
FT                   /note="WD 1"
FT   REPEAT          56..95
FT                   /note="WD 2"
FT   REPEAT          100..139
FT                   /note="WD 3"
FT   REPEAT          145..188
FT                   /note="WD 4"
FT   REPEAT          189..229
FT                   /note="WD 5"
FT   REPEAT          236..275
FT                   /note="WD 6"
FT   REPEAT          283..315
FT                   /note="WD 7"
SQ   SEQUENCE   315 AA;  35039 MW;  F3629E3273EBADE6 CRC64;
     MKMSKLSDLE GHEDRVWNVA WNPSGTILAS CGGDKSIRLW GLEGGSWVCK SVLLDGHQRT
     VRGVSWSNCG RYLASSSFDG TTCIWRRQDD TFESCATLEG HENEVKACGW SPSGRFLATC
     SRDKTVWIWE VGEDEEFECA SVQTCHSQDV KKVLWHPDRD ELASASYDNT IRFFCEEVDD
     WQCYCTLDKH ASTVWGLSFG PGPEPQLASC AADGSVYVWG TKGDRRSWEL CGTLERHPRP
     VYDVSWCRTR GFLATACGDN AVRVFVKDGG DCSWRLGCTL TQAHSQDVNS VSWSPSGGLL
     ASAGDDGYVR LWQID