ID   CIAO1_LODEL             Reviewed;         415 AA.
AC   A5E2R6;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=LELG_03903;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CH981528; EDK45724.1; -; Genomic_DNA.
DR   RefSeq; XP_001524871.1; XM_001524821.1.
DR   AlphaFoldDB; A5E2R6; -.
DR   SMR; A5E2R6; -.
DR   STRING; 379508.A5E2R6; -.
DR   EnsemblFungi; EDK45724; EDK45724; LELG_03903.
DR   GeneID; 5232161; -.
DR   KEGG; lel:LELG_03903; -.
DR   VEuPathDB; FungiDB:LELG_03903; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; A5E2R6; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..415
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382517"
FT   REPEAT          9..48
FT                   /note="WD 1"
FT   REPEAT          79..131
FT                   /note="WD 2"
FT   REPEAT          160..200
FT                   /note="WD 3"
FT   REPEAT          207..246
FT                   /note="WD 4"
FT   REPEAT          253..300
FT                   /note="WD 5"
FT   REPEAT          335..374
FT                   /note="WD 6"
FT   REPEAT          380..415
FT                   /note="WD 7"
FT   REGION          45..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  46023 MW;  1B81C65B5BB80212 CRC64;
     MKLLHSIKAH DDKVWSLSSH PTLPLLATAS TDKCSNIYRL SCSNASSSSS SSSPPSPPSP
     PSSSSPRRNF PQIAHLEDTH RRSVRSVSFK PPMGGIDHQD SNILDLPALA SGSFDSTISI
     WGIDEPDDDN TYEIEEIIAN QKEFLASPGN EWNLMAVIEG HENEIKAVDW NFSGRYLASC
     SRDKTVWIWE TDPETLEEFE CVAVLTDHTQ DVKHVTWHPT RNLLASSSYD DTIRVYKQEF
     DDDEWSCVGM IDGHEGTVWC SKFESPKSPK AKDGTTRLVS VSDDLSARVW ASKDNTGFNG
     GSEQLQSQSQ THLPSSIRHN AEEMVWEQES TLPQIHTHAI YSVAWSSSSG KIATAGSDGR
     IVVYKETNAG WEVENIQESA HGVYEINCVI WAKLDLDQEV LISGGDDGNV NIWEV