ID   CIAO1_MONBE             Reviewed;         506 AA.
AC   A9VDW7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog {ECO:0000255|HAMAP-Rule:MF_03037};
GN   ORFNames=30417;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CH991591; EDQ84290.1; -; Genomic_DNA.
DR   RefSeq; XP_001750920.1; XM_001750868.1.
DR   AlphaFoldDB; A9VDW7; -.
DR   SMR; A9VDW7; -.
DR   STRING; 81824.XP_001750920.1; -.
DR   EnsemblProtists; EDQ84290; EDQ84290; MONBRDRAFT_30417.
DR   GeneID; 5896175; -.
DR   KEGG; mbr:MONBRDRAFT_30417; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   InParanoid; A9VDW7; -.
DR   OMA; AIWSKSS; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 2.
DR   Pfam; PF00400; WD40; 6.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..506
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein CIAO1 homolog"
FT                   /id="PRO_0000382531"
FT   REPEAT          157..196
FT                   /note="WD 1"
FT   REPEAT          202..241
FT                   /note="WD 2"
FT   REPEAT          246..281
FT                   /note="WD 3"
FT   REPEAT          282..320
FT                   /note="WD 4"
FT   REPEAT          327..366
FT                   /note="WD 5"
FT   REPEAT          418..457
FT                   /note="WD 6"
FT   REPEAT          469..506
FT                   /note="WD 7"
SQ   SEQUENCE   506 AA;  55378 MW;  1556EB249FB75035 CRC64;
     MACSCLLMAS MQTLPGPGAF RTENGTLYLA FQEYYEAPQD PHNMADALSQ TLSNSSLSQT
     LLSQTLISHT FLSQTLLSNS SLSHSLTLSQ NSQTLLSQTL LSQTLLSLLS LTLSHSLKTL
     SNSFFSLKLF SLKLLDVFSL SHTRTSTRED GGDGQDGHED RVWDVKWSPT GAVLASSSGD
     QTVRLWTREA RDWVCLSTLE GPQKGTIRSL SWGREGNYLA AASFDSTTCV WEKGPSGFEC
     FATLEGHENE VKGVAFSASG DYIATWFADE EEFDCAAILA EHSQDVKAVA WHPTRDLLAS
     CSYDNTIRFY RADPDNADWI CCDTLSDNQS TVWKICFNAD GSRLAAVGDD RTLRVYQAFP
     PGNPQGAALP AHSSIYAPCL RNTLHSAINR LVCSDFAGIV TPSASDDKWK CIATITGQHT
     RPIYSVDWDP ETNILATAGG DNIVRLFRET AVQPDTNTPS YELIGQFQAH DQDLNGLAWA
     PNQPDLQHRL LATCADDGLH VGNHKS