ID   CIAO1_NEMVE             Reviewed;         327 AA.
AC   A7RWD2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog {ECO:0000255|HAMAP-Rule:MF_03037};
GN   ORFNames=v1g226592;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; DS469546; EDO44295.1; -; Genomic_DNA.
DR   RefSeq; XP_001636358.1; XM_001636308.1.
DR   AlphaFoldDB; A7RWD2; -.
DR   SMR; A7RWD2; -.
DR   STRING; 45351.EDO44295; -.
DR   EnsemblMetazoa; EDO44295; EDO44295; NEMVEDRAFT_v1g226592.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; A7RWD2; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; A7RWD2; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..327
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein CIAO1 homolog"
FT                   /id="PRO_0000382496"
FT   REPEAT          3..42
FT                   /note="WD 1"
FT   REPEAT          48..87
FT                   /note="WD 2"
FT   REPEAT          92..131
FT                   /note="WD 3"
FT   REPEAT          137..176
FT                   /note="WD 4"
FT   REPEAT          181..220
FT                   /note="WD 5"
FT   REPEAT          239..278
FT                   /note="WD 6"
FT   REPEAT          290..327
FT                   /note="WD 7"
SQ   SEQUENCE   327 AA;  36793 MW;  161BA96C95DBC87E CRC64;
     MTGHEDRVWS VAWSPNGFVL ASCGGDKTIR IWGKEGDKWI CKTILEDGHQ RTIRSLGWSP
     CGTFLASASF DATTCIWDQK SGEFECNATL EGHENEVKSV DWSVSGSLLA TCGRDKSVWI
     WEVQEDDEYE CASVIHSHTQ DVKKVVWHPT KEILASCSYD DTIKLYKEDE DDWSCCDTLE
     GHESTVWSIS FDGSGDRIVS CSDDKTVRIW KSYPPGNQEG VVVSGKHTKW KCVCVLSGYH
     DRTIYDVHWS KVSGLIATAS GDDCIRIFKE DTNSDRNQPS FQLVATQRKA HSMDVNSICW
     HPKDENILAT CSDDGTVKLW RFTPAEE