ID   CIAO1_NEOFI             Reviewed;         462 AA.
AC   A1D3I2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=cia1; ORFNames=NFIA_016710;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS027688; EAW22975.1; -; Genomic_DNA.
DR   RefSeq; XP_001264872.1; XM_001264871.1.
DR   AlphaFoldDB; A1D3I2; -.
DR   SMR; A1D3I2; -.
DR   STRING; 36630.CADNFIAP00000894; -.
DR   EnsemblFungi; EAW22975; EAW22975; NFIA_016710.
DR   GeneID; 4591423; -.
DR   KEGG; nfi:NFIA_016710; -.
DR   VEuPathDB; FungiDB:NFIA_016710; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..462
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382520"
FT   REPEAT          15..57
FT                   /note="WD 1"
FT   REPEAT          61..103
FT                   /note="WD 2"
FT   REPEAT          153..192
FT                   /note="WD 3"
FT   REPEAT          200..239
FT                   /note="WD 4"
FT   REPEAT          244..310
FT                   /note="WD 5"
FT   REPEAT          344..383
FT                   /note="WD 6"
FT   REPEAT          418..459
FT                   /note="WD 7"
FT   REGION          116..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  50824 MW;  92305E35939DB000 CRC64;
     MAAESSSQLS LLSDLTPPSL ERTWLSAPHP TLPIVATCSS DKTVRVYSLT NFRLLSTITG
     GHKRSVRTCA WKPHVKGESV LATGSFDATV GIWRRWDSYG QTERGIEDWH RADTHDHADD
     MTNGNGAAGI DNDGGDGADE DDEEWRFAVL LDGHDSEVKS VSWSPSGMLL ATCSRDKSIW
     IWEDLDDGDN NFETVAVMQE HQGDVKCVAW HPVEECLASA SYDDTIRLWR EDLDDWGQVA
     CIKGHQGTVW CVDWEGAENV PSAPTDLADG DLATAQWKKA HALSGPRLVS CSDDRTVRIW
     RRQPKEQQQH QAQPSPFGGS GIPSIIRPTG SDEFWDEECV LPQAHDLSIY TVAWSKRTGR
     LASVGADGRI VVYEERLVVG STAETMETDP PTSADGTAAD SPAALRTEWR VIATVDGAHG
     IYEINHVSWA KRADRGRTEG TDEEVLITTA DDGTVKVWTL KM