ID   CIAO1_PENRW             Reviewed;         455 AA.
AC   B6H7A3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=cia1; ORFNames=Pc16g01970;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AM920431; CAP92867.1; -; Genomic_DNA.
DR   RefSeq; XP_002560570.1; XM_002560524.1.
DR   AlphaFoldDB; B6H7A3; -.
DR   SMR; B6H7A3; -.
DR   STRING; 1108849.XP_002560570.1; -.
DR   PRIDE; B6H7A3; -.
DR   EnsemblFungi; CAP92867; CAP92867; PCH_Pc16g01970.
DR   GeneID; 8313929; -.
DR   KEGG; pcs:Pc16g01970; -.
DR   VEuPathDB; FungiDB:PCH_Pc16g01970; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   BioCyc; PCHR:PC16G01970-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c16.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..455
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382522"
FT   REPEAT          8..55
FT                   /note="WD 1"
FT   REPEAT          59..101
FT                   /note="WD 2"
FT   REPEAT          148..187
FT                   /note="WD 3"
FT   REPEAT          195..234
FT                   /note="WD 4"
FT   REPEAT          266..311
FT                   /note="WD 5"
FT   REPEAT          343..382
FT                   /note="WD 6"
FT   REPEAT          413..455
FT                   /note="WD 7"
FT   REGION          103..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   455 AA;  50057 MW;  6D6BC3867471446D CRC64;
     MSPKVTITHL SDLTPPSQER TWLTAPHPTL PLVATCSSDK TIRVYSLTNF TLLSTITGGH
     KRSVRTAAWK PHMTGESVLA TGSFDATVGI WRRWDSYGQE GDAGMGMSSG DKQIPTDIST
     AASNGTGTDT ADREEDEEEW RFAVLLDGHD SEVKSVSWSA SGMLLATCSR DKSIWIWEDL
     DDGDNNFETV AVMQEHGGDV KCVSWHPSEE CLASGSYDDT IRLWREDLDD WGQVACIKGH
     GGTVWFLDWE GEETEGNWSG PVADSVSESA LSALQAQWRS QRALSGPRLL SCSDDRTVRV
     WRRQPKESQQ TGPLSSATTG IPSIIRPTGT DEVWEEDAVL PRAHELPVYA VAWSKRTGLV
     ASTGADGRIA LYEERFVTRE QEQEQQADSD AMDTTSGDVL RTEWVLVGVQ DGAHGIYEIN
     HVAWAKRADR RPGGEEEVLV STADDGSVKV WTLTR