ID   CIAO1_PICGU             Reviewed;         382 AA.
AC   A5DHD2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=PGUG_02683;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH408157; EDK38585.2; -; Genomic_DNA.
DR   RefSeq; XP_001484954.1; XM_001484904.1.
DR   AlphaFoldDB; A5DHD2; -.
DR   SMR; A5DHD2; -.
DR   STRING; 4929.XP_001484954.1; -.
DR   EnsemblFungi; EDK38585; EDK38585; PGUG_02683.
DR   GeneID; 5127026; -.
DR   KEGG; pgu:PGUG_02683; -.
DR   VEuPathDB; FungiDB:PGUG_02683; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; A5DHD2; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..382
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382524"
FT   REPEAT          9..48
FT                   /note="WD 1"
FT   REPEAT          55..107
FT                   /note="WD 2"
FT   REPEAT          138..178
FT                   /note="WD 3"
FT   REPEAT          185..224
FT                   /note="WD 4"
FT   REPEAT          231..278
FT                   /note="WD 5"
FT   REPEAT          303..342
FT                   /note="WD 6"
FT   REPEAT          349..382
FT                   /note="WD 7"
SQ   SEQUENCE   382 AA;  42938 MW;  2AD522A72EA7C7C7 CRC64;
     MRLLYGIRAH HDKIWSVSSH QKLPLLATGS SDKTSAIFRL SETEKFPRVT TLDDTHTRSI
     RSVMFKPPID DTVVDENELL DPPTLAMGSF DAKLSVWQAE LPQDNDEDMD QEPREIWKQE
     RKVVERAAQW ELMAVIEGHE HEVKAVAWNC HGSLVASCSR DKTIWIWETD PDTLEEFECI
     SVLTEHQQDV KHVIWHPTQN LLASSSYDDT ICIYRQEYDD DDWGCAAVLN GHQGTVWCSA
     FEHPKSPSAS ETTVRLVSAS DDLTVRIWST SKEGSETNHD ALPSSIKSSN EMQWDQECIL
     PSAHTYPVYS VVWSSVSGRI ASAGADGKIA VYKQTDGVWE IEGVTSAAHG VHEINTLAWS
     KLDDNREVLV SGGDDGYVNV WE