ID   CIAO1_PICST             Reviewed;         361 AA.
AC   A3LVM1;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=PICST_60492;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000499; ABN67145.2; -; Genomic_DNA.
DR   RefSeq; XP_001385174.2; XM_001385137.1.
DR   AlphaFoldDB; A3LVM1; -.
DR   SMR; A3LVM1; -.
DR   STRING; 4924.XP_001385174.2; -.
DR   EnsemblFungi; ABN67145; ABN67145; PICST_60492.
DR   GeneID; 4839450; -.
DR   KEGG; pic:PICST_60492; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; A3LVM1; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..361
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382525"
FT   REPEAT          10..49
FT                   /note="WD 1"
FT   REPEAT          56..105
FT                   /note="WD 2"
FT   REPEAT          120..160
FT                   /note="WD 3"
FT   REPEAT          167..206
FT                   /note="WD 4"
FT   REPEAT          213..265
FT                   /note="WD 5"
FT   REPEAT          280..319
FT                   /note="WD 6"
FT   REPEAT          327..361
FT                   /note="WD 7"
SQ   SEQUENCE   361 AA;  40534 MW;  6E8E4DC806E19EF1 CRC64;
     MVSLIKSIKA HSDKAWSVSA HKTVPLLATA STDKTSKIYK LSVKQNFPQV AQLEDTHKRS
     VRAVSFKPPL PGVESNFLDL PALASGSFDS TISIWGIDEP ETEILSSPRN EWNLMAIIEG
     HENEIKAVGW NHNGSLLASC SRDKTVWIWE TDPETLEEFE CISVLNDHQH DIKHVVWHPH
     QNLLASSSYD DTIRLYKQDL DDDDWSCVGV LNGHEGTVWC SQFEDNHRHQ ESNESSNRSK
     IRLVSVSDDM TARIWSKYIP SSIKHKSEMV WEQESILPPV HQYPIYSVAW SAQSGKIATV
     GSDGKIVIYI EGDDNSWSID SVKESAHGVH EINSIIWALL DDQSEVLVTA GDDGCVNIWK
     P