ID   CIAO1_SCHJA             Reviewed;         352 AA.
AC   Q5DFU0;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog {ECO:0000255|HAMAP-Rule:MF_03037};
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16617374; DOI=10.1371/journal.ppat.0020029;
RA   Liu F., Lu J., Hu W., Wang S.-Y., Cui S.-J., Chi M., Yan Q., Wang X.-R.,
RA   Song H.-D., Xu X.-N., Wang J.-J., Zhang X.-L., Zhang X., Wang Z.-Q.,
RA   Xue C.-L., Brindley P.J., McManus D.P., Yang P.-Y., Feng Z., Chen Z.,
RA   Han Z.-G.;
RT   "New perspectives on host-parasite interplay by comparative transcriptomic
RT   and proteomic analyses of Schistosoma japonicum.";
RL   PLoS Pathog. 2:268-281(2006).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AY813584; AAW25316.1; -; mRNA.
DR   AlphaFoldDB; Q5DFU0; -.
DR   SMR; Q5DFU0; -.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 2.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Repeat; WD repeat.
FT   CHAIN           1..352
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein CIAO1 homolog"
FT                   /id="PRO_0000382497"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT   REPEAT          106..145
FT                   /note="WD 3"
FT   REPEAT          151..190
FT                   /note="WD 4"
FT   REPEAT          195..234
FT                   /note="WD 5"
FT   REPEAT          245..284
FT                   /note="WD 6"
FT   REPEAT          303..352
FT                   /note="WD 7"
SQ   SEQUENCE   352 AA;  39404 MW;  DF133053D4476963 CRC64;
     MLNVREVQKL KASNKRLWSL SWNHKGSVLI SSGEDRVIKL WAKCNDQLWG SSFSLPEAHK
     KSIRCVTWSP CGTYIASASF DGTVTIWKIS EAHSAPEMEA LVSLEGHTSE VKCVAWCPSG
     HLIATCGRDK SVWLWEFDDE EDVQCVSVLQ PHSQDVKSVA WHPHGEVLVS TSYDNKINVY
     REELDDWTVF AQLSGHDSTV WKAEFSPSGD ILASCSDDLC VKLWSWEGVC GKSSSWMCIA
     TLSGYHTRTI FDLNWSPDSQ LLASCGSDNR LCIYKMPANG LTHIGGKPCF EEPPVLWGHV
     PNAHSEDVNC VRWKPGNITD ISHSESISNC HLFLTTASDD GYIKFWSIEY EL