ID   CIAO1_TRIAD             Reviewed;         313 AA.
AC   B3RNR8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog {ECO:0000255|HAMAP-Rule:MF_03037};
GN   ORFNames=TRIADDRAFT_20668;
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax.
OX   NCBI_TaxID=10228;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999;
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; DS985242; EDV28061.1; -; Genomic_DNA.
DR   RefSeq; XP_002109895.1; XM_002109859.1.
DR   AlphaFoldDB; B3RNR8; -.
DR   SMR; B3RNR8; -.
DR   STRING; 10228.TriadP20668; -.
DR   EnsemblMetazoa; TriadT20668; TriadP20668; TriadG20668.
DR   GeneID; 6751110; -.
DR   KEGG; tad:TRIADDRAFT_20668; -.
DR   CTD; 6751110; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; B3RNR8; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; B3RNR8; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..313
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein CIAO1 homolog"
FT                   /id="PRO_0000382498"
FT   REPEAT          1..35
FT                   /note="WD 1"
FT   REPEAT          43..82
FT                   /note="WD 2"
FT   REPEAT          87..126
FT                   /note="WD 3"
FT   REPEAT          133..172
FT                   /note="WD 4"
FT   REPEAT          177..216
FT                   /note="WD 5"
FT   REPEAT          227..266
FT                   /note="WD 6"
FT   REPEAT          277..313
FT                   /note="WD 7"
SQ   SEQUENCE   313 AA;  35608 MW;  0B4D3A4217199FD7 CRC64;
     MTTVAFLPLS FPFLIFNFGQ YIRIWAKNSD SDQWTCKSIL TEGHTRTIRS VAWSPCGNYL
     ASCSFDATIC IWSKKDGDFE CMATLEGHEN EVKCVNWSSS GVYLASCSRD KSAWIWEFIE
     EDEEYECASV LTDHSQDVKH VVWSPKENAL VSASYDNTIK IYKEVDDDWE CSHTLIGHES
     TVWSLSFHSS GELFVSCGDD KVLKIWKCLK SGPSDVKWIS ICTIAGYHNR PIYDVDWSKL
     NNKIATACGD DAIRIFSIVR ITISISNQLL FIAYYQAHNH DVNVVRWHPK VDNILASGSD
     DNCIKIWKVH SNN