ID   CIAO1_VANPO             Reviewed;         347 AA.
AC   A7TLU2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=Kpol_526p37;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; DS480417; EDO16784.1; -; Genomic_DNA.
DR   RefSeq; XP_001644642.1; XM_001644592.1.
DR   AlphaFoldDB; A7TLU2; -.
DR   SMR; A7TLU2; -.
DR   STRING; 436907.A7TLU2; -.
DR   EnsemblFungi; EDO16784; EDO16784; Kpol_526p37.
DR   GeneID; 5544943; -.
DR   KEGG; vpo:Kpol_526p37; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; A7TLU2; -.
DR   OMA; DDWECAA; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; A7TLU2; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..347
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382528"
FT   REPEAT          11..48
FT                   /note="WD 1"
FT   REPEAT          62..101
FT                   /note="WD 2"
FT   REPEAT          122..161
FT                   /note="WD 3"
FT   REPEAT          168..207
FT                   /note="WD 4"
FT   REPEAT          212..255
FT                   /note="WD 5"
FT   REPEAT          266..304
FT                   /note="WD 6"
FT   REPEAT          311..347
FT                   /note="WD 7"
SQ   SEQUENCE   347 AA;  38871 MW;  51946162FC9C943E CRC64;
     MSLNLVKALK LHNEKIWDID CYKGLLATAS TDRRIKIVNI GDIGDGLVSD DGRLLDELDD
     SSHKKTVRSV AWRPHSTILA AGSFDSTVSI WAKDENDGDA DGDGGVDDPS SFSMELLAVI
     EGHENEVKSV AWSKDGYFLA TCSRDKSVWI WESDEMGEEY ECISVLQEHS QDVKHVVWHP
     FKDILASSSY DDTIRIWKEY DDDWEAAAVL KGHEGTVWGS DFEKNVNTDI VRLCSGSDDT
     TVKIWRCVSN ESIEEDWICE ATLPNVHGKP VYSVSWSEDG LIASAGSDGM LVIYKENKDN
     VWEVVAKHEH SHSIYEINVV KWIKLNNGKS YLATAGDDGY VNIWAYN