CIAO1_XENTR
ID CIAO1_XENTR Reviewed; 333 AA.
AC Q28DW0;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
DE AltName: Full=WD repeat-containing protein 39 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=ciao1; Synonyms=wdr39; ORFNames=TEgg053g13.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into extramitochondrial Fe/S proteins.
CC {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SUBUNIT: Component of the CIA complex. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; CR848572; CAJ81275.1; -; mRNA.
DR EMBL; BC127279; AAI27280.1; -; mRNA.
DR RefSeq; NP_001016887.1; NM_001016887.2.
DR AlphaFoldDB; Q28DW0; -.
DR SMR; Q28DW0; -.
DR STRING; 8364.ENSXETP00000009442; -.
DR PaxDb; Q28DW0; -.
DR DNASU; 549641; -.
DR Ensembl; ENSXETT00000009442; ENSXETP00000009442; ENSXETG00000004336.
DR GeneID; 549641; -.
DR KEGG; xtr:549641; -.
DR CTD; 9391; -.
DR Xenbase; XB-GENE-1010751; ciao1.
DR eggNOG; KOG0645; Eukaryota.
DR HOGENOM; CLU_000288_57_8_1; -.
DR InParanoid; Q28DW0; -.
DR OMA; DDWECAA; -.
DR OrthoDB; 793298at2759; -.
DR TreeFam; TF318181; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000004336; Expressed in brain and 14 other tissues.
DR GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19920; PTHR19920; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..333
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein ciao1"
FT /id="PRO_0000281109"
FT REPEAT 14..53
FT /note="WD 1"
FT REPEAT 59..98
FT /note="WD 2"
FT REPEAT 103..142
FT /note="WD 3"
FT REPEAT 148..187
FT /note="WD 4"
FT REPEAT 192..231
FT /note="WD 5"
FT REPEAT 246..285
FT /note="WD 6"
FT REPEAT 297..333
FT /note="WD 7"
SQ SEQUENCE 333 AA; 37479 MW; AED9CFBBED6F2AD6 CRC64;
MKDTLTLLSR VSAHPDSRCW FLAWNPSGTL LASCGGDRTI RIWGKDGDNW VCKSVLGEGH
QRTVRKVSWS PCGNYLASAS FDATTCIWMK KKEEFECITT LEGHENEVKS VAWAPSGSLL
ATCSRDKSVW VWEVDEEEEY ECVSVLNSHT QDVKHVVWHP NQELLASASY DDSVKLYREE
EDDWVCCATL EGHTSTVWSL AFDQTGEQLA TCSDDKTVRI WRQLGTGEQG SKSDPNWKCV
CTLTGYHTRT VYDVNWNHLT GAIATACGDD AVRIFEEDPG SDPLQPTFSL TAHMPRAHTQ
DVNCVTWHPK EPNLLASCSD DGEMAFWRYQ KPE
