ID   CIAO1_YARLI             Reviewed;         332 AA.
AC   Q6CBI8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   OrderedLocusNames=YALI0C18381g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CR382129; CAG82294.1; -; Genomic_DNA.
DR   RefSeq; XP_501974.1; XM_501974.1.
DR   AlphaFoldDB; Q6CBI8; -.
DR   SMR; Q6CBI8; -.
DR   STRING; 4952.CAG82294; -.
DR   EnsemblFungi; CAG82294; CAG82294; YALI0_C18381g.
DR   GeneID; 2909977; -.
DR   KEGG; yli:YALI0C18381g; -.
DR   VEuPathDB; FungiDB:YALI0_C18381g; -.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q6CBI8; -.
DR   OMA; AIWSKSS; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..332
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382529"
FT   REPEAT          9..48
FT                   /note="WD 1"
FT   REPEAT          52..93
FT                   /note="WD 2"
FT   REPEAT          98..137
FT                   /note="WD 3"
FT   REPEAT          144..183
FT                   /note="WD 4"
FT   REPEAT          188..230
FT                   /note="WD 5"
FT   REPEAT          257..295
FT                   /note="WD 6"
FT   REPEAT          302..332
FT                   /note="WD 7"
SQ   SEQUENCE   332 AA;  36806 MW;  D4563A4EA4514ECF CRC64;
     MQLIKALKGH TDRAWAASVH PNLPLLATCS GDKTVRIYNT NNWELVTTIT EGHNRSVRSV
     AWKPSGSSPS LALGSFDSTV SIWGKEDDEW QFLAAIEGHE NEVKGVSWSC DGQLLATCSR
     DKSIWVWEAD DMNDEFECIS VLQDHTQDVK HVAWHPSEMV FASASYDDTV RLWREDDDDW
     ICVADLGGHE STVWGCAFEP SEGSDLRLVS CSDDKTCIVW KKEGQVGGTG DHSGIRPAFR
     ADPLSEEWIQ QATLPEAHTR AIYSVAWNKN GRIASTGADG KLVVYKENGP GQWVVESEVE
     NAHGVYEVND VVWLDDKLVT SGDDGVVNIW EV