ID   CICD_CICFL              Reviewed;          55 AA.
AC   P83282;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Cicadin;
DE   Flags: Fragment;
OS   Cicada flammata.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Auchenorrhyncha; Cicadoidea; Cicadidae;
OC   Cicadinae; Cicadini; Cicada.
OX   NCBI_TaxID=186872 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RX   PubMed=11814612; DOI=10.1016/s0196-9781(01)00573-3;
RA   Wang H., Ng T.B.;
RT   "Isolation of cicadin, a novel and potent antifungal peptide from dried
RT   juvenile cicadas.";
RL   Peptides 23:7-11(2002).
CC   -!- FUNCTION: Possesses antifungal activity against B.cinerea,
CC       M.arachidicola, F.oxysporum, R.solani and C.comatus.
CC       {ECO:0000269|PubMed:11814612}.
CC   -!- FUNCTION: Suppresses the activity of HIV-1 reverse transcriptase and
CC       stimulates the proliferation of murine splenocytes.
CC       {ECO:0000269|PubMed:11814612}.
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DR   AlphaFoldDB; P83282; -.
DR   SMR; P83282; -.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:UniProtKB.
DR   Gene3D; 2.40.50.60; -; 1.
DR   InterPro; IPR023112; Antifungal-protein_dom_sf.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide.
FT   CHAIN           1..>55
FT                   /note="Cicadin"
FT                   /id="PRO_0000089745"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         55
FT                   /evidence="ECO:0000303|PubMed:11814612"
SQ   SEQUENCE   55 AA;  6596 MW;  A232880A33519112 CRC64;
     NEYHGFVDKA NNENKRKKQQ GRDDFVVKPN NFANRRRKDD YNENYYDDVD AADVV