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CICH_TORMA
ID   CICH_TORMA              Reviewed;         805 AA.
AC   P21564;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Chloride channel protein;
DE   AltName: Full=ClC-0;
OS   Torpedo marmorata (Marbled electric ray).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Torpedo.
OX   NCBI_TaxID=7788;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Electric organ;
RX   PubMed=2174129; DOI=10.1038/348510a0;
RA   Jentsch T.J., Steinmeyer K., Schwarz G.;
RT   "Primary structure of Torpedo marmorata chloride channel isolated by
RT   expression cloning in Xenopus oocytes.";
RL   Nature 348:510-514(1990).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 525-774, IDENTIFICATION BY MASS
RP   SPECTROMETRY, AND SUBUNIT.
RX   PubMed=16472749; DOI=10.1016/j.str.2005.10.008;
RA   Meyer S., Dutzler R.;
RT   "Crystal structure of the cytoplasmic domain of the chloride channel ClC-
RT   0.";
RL   Structure 14:299-307(2006).
CC   -!- FUNCTION: Voltage-gated chloride channel. This channel is thought to
CC       ensure the high conductance of the non-innervated membrane of the
CC       electrocyte necessary for efficient current generation caused by sodium
CC       influx through the acetylcholine receptor at the innervated membrane.
CC   -!- SUBUNIT: Homodimer. Each subunit contains a channel ('Double barreled
CC       channel'). {ECO:0000269|PubMed:16472749}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride channels
CC       and proton-coupled anion transporters that exchange chloride or another
CC       anion for protons. The absence of conserved gating glutamate residues
CC       is typical for family members that function as channels (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClC-0
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X56758; CAA40078.1; -; mRNA.
DR   PIR; S13410; S13410.
DR   PDB; 2D4Z; X-ray; 3.10 A; A/B=525-774.
DR   PDBsum; 2D4Z; -.
DR   AlphaFoldDB; P21564; -.
DR   SMR; P21564; -.
DR   DIP; DIP-29086N; -.
DR   EvolutionaryTrace; P21564; -.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.580.10; -; 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002242; Cl_channel-0.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01111; CLCHANNEL0.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF81340; SSF81340; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   1: Evidence at protein level;
KW   3D-structure; CBS domain; Chloride; Chloride channel; Glycoprotein;
KW   Ion channel; Ion transport; Membrane; Repeat; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..805
FT                   /note="Chloride channel protein"
FT                   /id="PRO_0000094464"
FT   TOPO_DOM        1..48
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        49..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        93..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        125..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        141..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        166..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        201..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        217..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        237..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        283..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        320..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        416..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        456..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        471..472
FT                   /note="Note=Loop between two helices"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        473..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   INTRAMEM        485..489
FT                   /note="Note=Loop between two helices"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        490..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        508..805
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   DOMAIN          543..601
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          719..776
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   REGION          606..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           122..126
FT                   /note="Selectivity filter part_1"
FT                   /evidence="ECO:0000250"
FT   MOTIF           164..168
FT                   /note="Selectivity filter part_2"
FT                   /evidence="ECO:0000250"
FT   MOTIF           416..420
FT                   /note="Selectivity filter part_3"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        669..684
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         123
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /evidence="ECO:0000250"
FT   BINDING         418
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /evidence="ECO:0000250"
FT   BINDING         512
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        365
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   STRAND          541..546
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   HELIX           556..565
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   STRAND          569..575
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   TURN            577..579
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   STRAND          581..587
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   HELIX           588..600
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   STRAND          603..605
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   HELIX           697..707
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   HELIX           732..742
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   STRAND          745..751
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   STRAND          754..760
FT                   /evidence="ECO:0007829|PDB:2D4Z"
FT   HELIX           761..769
FT                   /evidence="ECO:0007829|PDB:2D4Z"
SQ   SEQUENCE   805 AA;  88888 MW;  4CD2FA48AE06FC6D CRC64;
     MSHEKNEASG YPEAQSWKSQ EAMLGARTEV SRWRAVKNCL YRHLVKVLGE DWIFLLLLGA
     LMALVSWAMD FIGSRGLRFY KYLFALVEGN IGLQYLVWVC YPLALILFSS LFCQIVSPQA
     VGSGIPELKT IIRGAVLHEY LTLRTFVAKT VGLTVALSAG FPLGKEGPFV HIASICATLL
     NQLLCFISGR REEPYYLRAD ILTVGCALGI SCCFGTPLAG VLFSIEVTCS HFGVRSYWRG
     FLGGAFSAFI FRVLSVWVKD TVTLTALFKT NFRGDIPFDL QEMPAFAIIG IASGFFGALF
     VYLNRQIIVF MRKKNFVTKI LKKQRLIYPA VVTFVLATLR FPPGVGQFFG AGLMPRETIN
     SLFDNYTWTK TIDPRGLGNS AQWFIPHLNI FIVMALYFVM HFWMAALAVT MPVPCGAFVP
     VFNLGAVLGR FVGELMALLF PDGLVSNGNL YHILPGEYAV IGAAAMTGAV THAVSTAVIC
     FELTGQISHV LPMMVAVILA NMVAQGLQPS LYDSIIQIKK LPYLPELSWS SANKYNIQVG
     DIMVRDVTSI ASTSTYGDLL HVLRQTKLKF FPFVDTPDTN TLLGSIDRTE VEGLLQRRIS
     AYRRQPAAAA EADEEGRNGE TGASFTGEAE SSFAYIDQED AEGQQREGLE AVKVQTEDPR
     PPSPVPAEEP TQTSGIYQKK QKGTGQVASR FEEMLTLEEI YRWEQREKNV VVNFETCRID
     QSPFQLVEGT SLQKTHTLFS LLGLDRAYVT SMGKLVGVVA LAEIQAAIEG SYQKGFRLPP
     PLASFRDVKH ARNSGRTATS NSSGK
 
 
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