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CIC_DROME
ID   CIC_DROME               Reviewed;        1832 AA.
AC   Q9U1H0; A8JR51; B5RIQ9; Q29R05; Q9VDN9;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 166.
DE   RecName: Full=Putative transcription factor capicua;
DE   AltName: Full=Protein fettucine;
GN   Name=cic; Synonyms=fet; ORFNames=CG43122;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, INTERACTION WITH GRO,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RC   TISSUE=Embryo;
RX   PubMed=10652276;
RA   Jimenez G., Guichet A., Ephrussi A., Casanova J.;
RT   "Relief of gene repression by torso RTK signaling: role of capicua in
RT   Drosophila terminal and dorsoventral patterning.";
RL   Genes Dev. 14:224-231(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RA   Stapleton M., Carlson J.W., Booth B., Chavez C., Frise E., George R.A.,
RA   Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=11714680; DOI=10.1242/dev.128.22.4553;
RA   Goff D.J., Nilson L.A., Morisato D.;
RT   "Establishment of dorsal-ventral polarity of the Drosophila egg requires
RT   capicua action in ovarian follicle cells.";
RL   Development 128:4553-4562(2001).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=11861482; DOI=10.1242/dev.129.4.993;
RA   Roch F., Jimenez G., Casanova J.;
RT   "EGFR signalling inhibits capicua-dependent repression during specification
RT   of Drosophila wing veins.";
RL   Development 129:993-1002(2002).
RN   [7]
RP   FUNCTION.
RX   PubMed=15510215; DOI=10.1038/sj.emboj.7600457;
RA   Cinnamon E., Gur-Wahnon D., Helman A., St Johnston D., Jimenez G.,
RA   Paroush Z.;
RT   "Capicua integrates input from two maternal systems in Drosophila terminal
RT   patterning.";
RL   EMBO J. 23:4571-4582(2004).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-49 AND THR-1716, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
CC   -!- FUNCTION: Transcriptional repressor required for the specification of
CC       numerous cell types during embryonic development. Required for terminal
CC       patterning of early embryos. May associate with gro to repress tll and
CC       hkb, restricting their expression to embryonic terminal poles where
CC       they initiate correct development of head and tail structures. Required
CC       for dorsoventral patterning of oocytes and early embryos. Cooperates
CC       with dl to repress zen and other dorsal specific genes within the
CC       embryo and promotes expression of the ventralizing factor pip in
CC       ovarian follicle cells. Required during wing development for the
CC       specification of intervein areas, where it mediates localized
CC       repression of vein specific genes such as aos, dpp and vvl.
CC       {ECO:0000269|PubMed:10652276, ECO:0000269|PubMed:11714680,
CC       ECO:0000269|PubMed:11861482, ECO:0000269|PubMed:15510215}.
CC   -!- SUBUNIT: Interacts with gro. {ECO:0000269|PubMed:10652276}.
CC   -!- INTERACTION:
CC       Q9U1H0; P40417: rl; NbExp=3; IntAct=EBI-98330, EBI-867790;
CC       Q9U1H0; P28482: MAPK1; Xeno; NbExp=2; IntAct=EBI-98330, EBI-959949;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC       ECO:0000269|PubMed:10652276, ECO:0000269|PubMed:11714680,
CC       ECO:0000269|PubMed:11861482}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B;
CC         IsoId=Q9U1H0-1; Sequence=Displayed;
CC       Name=A;
CC         IsoId=Q9U1H0-2; Sequence=VSP_036477;
CC   -!- TISSUE SPECIFICITY: Expressed in the central region of embryos. Also
CC       expressed in ovarian follicle cells, the wing imaginal disks and the
CC       wing pouch. {ECO:0000269|PubMed:10652276, ECO:0000269|PubMed:11714680,
CC       ECO:0000269|PubMed:11861482}.
CC   -!- DEVELOPMENTAL STAGE: Expressed maternally in stage 1-3 blastoderm
CC       embryos. {ECO:0000269|PubMed:10652276}.
CC   -!- INDUCTION: Subject to local inactivation by the RAS-RAF-MAPK signal
CC       transduction pathway, which leads to relief of target gene repression.
CC       This pathway may be locally activated by a variety of ligands and
CC       receptor tyrosine kinases (RTKs) according to the developmental stage
CC       and tissue. In terminal patterning, activation of tor by the locally
CC       processed ligand trk may promote cic inactivation specifically at the
CC       embryonic terminal poles. In the developing wing, activation of Egfr by
CC       vn may lead to cic inactivation specifically in prospective vein
CC       tissue. {ECO:0000269|PubMed:10652276, ECO:0000269|PubMed:11861482}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABC86297.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ252268; CAB66144.1; -; mRNA.
DR   EMBL; AE014297; AAF55751.3; -; Genomic_DNA.
DR   EMBL; AE014297; ABW08708.1; -; Genomic_DNA.
DR   EMBL; BT044183; ACH92248.1; -; mRNA.
DR   EMBL; BT024235; ABC86297.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001097843.1; NM_001104373.2. [Q9U1H0-1]
DR   RefSeq; NP_524992.1; NM_080253.4. [Q9U1H0-2]
DR   AlphaFoldDB; Q9U1H0; -.
DR   SMR; Q9U1H0; -.
DR   BioGRID; 72791; 14.
DR   DIP; DIP-23664N; -.
DR   IntAct; Q9U1H0; 14.
DR   MINT; Q9U1H0; -.
DR   iPTMnet; Q9U1H0; -.
DR   PaxDb; Q9U1H0; -.
DR   PRIDE; Q9U1H0; -.
DR   DNASU; 53560; -.
DR   EnsemblMetazoa; FBtr0305026; FBpp0293563; FBgn0262582. [Q9U1H0-2]
DR   EnsemblMetazoa; FBtr0305027; FBpp0293564; FBgn0262582. [Q9U1H0-1]
DR   GeneID; 53560; -.
DR   KEGG; dme:Dmel_CG43122; -.
DR   UCSC; CG5067-RB; d. melanogaster.
DR   CTD; 23152; -.
DR   FlyBase; FBgn0262582; cic.
DR   VEuPathDB; VectorBase:FBgn0262582; -.
DR   eggNOG; KOG2746; Eukaryota.
DR   GeneTree; ENSGT00940000159960; -.
DR   HOGENOM; CLU_002375_0_0_1; -.
DR   InParanoid; Q9U1H0; -.
DR   SignaLink; Q9U1H0; -.
DR   BioGRID-ORCS; 53560; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 53560; -.
DR   PRO; PR:Q9U1H0; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0262582; Expressed in cleaving embryo and 31 other tissues.
DR   ExpressionAtlas; Q9U1H0; baseline and differential.
DR   Genevisible; Q9U1H0; DM.
DR   GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:FlyBase.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:FlyBase.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR   GO; GO:0046843; P:dorsal appendage formation; IMP:FlyBase.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:FlyBase.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IMP:FlyBase.
DR   GO; GO:0048592; P:eye morphogenesis; IMP:FlyBase.
DR   GO; GO:0007474; P:imaginal disc-derived wing vein specification; IMP:FlyBase.
DR   GO; GO:0007313; P:maternal specification of dorsal/ventral axis, oocyte, soma encoded; IMP:FlyBase.
DR   GO; GO:0030308; P:negative regulation of cell growth; IMP:FlyBase.
DR   GO; GO:0046621; P:negative regulation of organ growth; IGI:FlyBase.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:FlyBase.
DR   GO; GO:0007362; P:terminal region determination; IMP:FlyBase.
DR   GO; GO:0008293; P:torso signaling pathway; IDA:FlyBase.
DR   GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IGI:FlyBase.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1832
FT                   /note="Putative transcription factor capicua"
FT                   /id="PRO_0000048600"
FT   DNA_BIND        490..558
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          66..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          563..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          690..739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          784..845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..1832
FT                   /note="Interaction with gro"
FT   REGION          874..938
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1069..1105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1151..1178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1457..1602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1632..1668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1701..1733
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1789..1817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..184
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..714
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..730
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        826..845
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        877..914
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        915..938
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1498..1594
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1707..1723
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         1716
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   VAR_SEQ         887..1315
FT                   /note="Missing (in isoform A)"
FT                   /evidence="ECO:0000303|PubMed:10652276, ECO:0000303|Ref.4"
FT                   /id="VSP_036477"
SQ   SEQUENCE   1832 AA;  195662 MW;  1D2A2A8537BFB4D8 CRC64;
     MNAFQDFELG AKLYLQCLLS LSSSRSATPS YTSPVNHAGA SPLNAIAHSP VNVSATHRQN
     FFTPIANQSQ QQQQQQPVAV PLDSKWKTTP SPVLYNANNN SSNNNTSSSN NNNNSNWEVG
     SNSNTHVAAT AAATSTVGAQ PLPPQTTPVS LVMHAPPPQQ QPLQQQHHHH QPPPPPPASL
     PAPSAPPTSG SSSSHNSVGH ATSVIRISSS QQQHQQQQQH QQQAHPHVVV SGGQTFHPVI
     VDATQLSVPL PPTTVSFHQP NTPTSTAASV ASMSQDKMLA KNGYNAPWFK LLPHMTPMSK
     ASPAPVTPTL TTSASSYNVV MMQQQQQHQQ LQQQQQLQQQ QQSPPQMPLN HNNNHLIVSA
     PLSSPGKPLN CSMNDAKVAA AAAAAAVANQ RQKQQQEEPD DQLDDDVFET TTPGISANSK
     KQTAAMRLPT HNSNIRKLEE CHDDGAAGAP ATSAAKRRSQ SLSALQQQQQ QQQQAGAAGT
     AAGQPANKKI RRPMNAFMIF SKKHRKMVHK KHPNQDNRTV SKILGEWWYA LKPEQKAQYH
     ELASSVKDAH FKLHPEWKWC SKDRRKSSTS TATPGGKASG AAGTGDAKQR LVSVDGSDSL
     EHDMCPSTPG GSGSCGGQGI SSDLQGDIIP LTIDNYNSTC DEAPTTISMK GNGNGKLMKN
     ELPSDEDEQM LVVEEEQQQQ TVKKIDLHCR ERVNDSDMDD TPFDYRKQQP EANQRSAEEH
     STSGANGQAI NAPPLSGGER EITLKPKAIK AHPVLESNML PYTQMSIYTQ YTSPKNPIGV
     TPFQPTGGAF KSMPISPKGS GGKPEDAGSL QAHIKQEDIK QEPPSPYKLN NGSGSASGGG
     VVSAPPPNSG SVGAIFNFNV PTATALSQKQ FHYPMHHPHR SPTDLRDEEA DREEITQGTK
     SGESSEKDKP ALDDQERDEV EEEDEDEEDD DEDDEDDEQF MQELASVNAS AGFDDLVPYA
     MPKVVITPTP TPPPVATIVT PIKRKQFTIV RSLTPLQPSN SPHQQLKHLH QRRGETPPTV
     ITRVPTPTIN HFTIIRTQQH PHTHPHNTPP PLFFKQKVQG SPVIATVTTS TLSSSSSNPA
     NNEAPNKFSN FPTQHQPTTT TTISCNTNNN ATPIIRKLLT LQEGAELGGS HKGTGRAAIL
     YDALVLDTLH GQDEEEEEDE GNAEKQENPK VAGKEQVTTS QPATMLLITD VNAYNQQHVA
     GNAATPVSGA ATLRPVSFIS INACNKITLP ANARILTAAT ATSTAAGAAV TSQAGATLTV
     MTKASAATNH SSSNASDITI TAASAAPVPT SGSSIVMINS TTNPSTSSNS TSCSAAAHQA
     CVPSSPAGMG LGHAANIATP PASAPAQIMG GGPASQKMFF AMTHPYTLLQ RSHQPGTPSL
     EHLQLDAFAP GGYTLRNHNG LSSLPPPVSA QPTMLLHGYP PSHGVEPPAR SPSYKSMPST
     PKSATYLMSA PPERGMDGGM SGCASAAASG GDESDIDADG QQFILAPTPA QLGRAPLQRR
     KNLSQSKSES NVSFGANLGA SNGQHISRKL HSPTMMESSS PIIGHVNSSN LSSALPTPTS
     STTTPNSDEQ LPLTPTTSSS NSNLNQQQPK SPMKGAPGST AAALKKKNDE MNNSVLKQVD
     FEKKYKALPQ FQPEDCQSPS AIAVPSSPRV YGTNYRKKNT APPPVQKLMC EDDSIDEPAS
     APPTTTQRFF GPDFNNELKE LESSDQTGRS PRTPKTPLQS ARSDASEKGH RKVLETRRSL
     VLQLFAEHGN FPTAQATMAF QSKHSDVFPR KQDLQLKIRE VRQKLLGQAS CTPHSAGPNT
     PSDSNSSSTT LSASSTSLNM QTTSAADVFQ YY
 
 
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