CID4_ARATH
ID CID4_ARATH Reviewed; 595 AA.
AC Q94AM9; Q9LVJ8;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Polyadenylate-binding protein-interacting protein 4;
DE Short=PABP-interacting protein 4;
DE Short=Poly(A)-binding protein-interacting protein 4;
DE AltName: Full=PAM2-containing protein CID4;
DE AltName: Full=Protein CTC-INTERACTING DOMAIN 4;
GN Name=CID4; OrderedLocusNames=At3g14010; ORFNames=MDC16.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, PAM2 MOTIF, AND TISSUE SPECIFICITY.
RX PubMed=15650869; DOI=10.1007/s00438-004-1090-9;
RA Bravo J., Aguilar-Henonin L., Olmedo G., Guzman P.;
RT "Four distinct classes of proteins as interaction partners of the PABC
RT domain of Arabidopsis thaliana Poly(A)-binding proteins.";
RL Mol. Genet. Genomics 272:651-665(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q94AM9-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in cauline leaves, stems, rosette leaves,
CC immature siliques and primary inflorescences.
CC {ECO:0000269|PubMed:15650869}.
CC -!- DOMAIN: Contains a tandem repeat of a PAM2-like motif, which seems to
CC be involved in the binding to the PABC/CTC domain of PAB proteins.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02332.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB019229; BAB02332.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75452.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75453.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75454.1; -; Genomic_DNA.
DR EMBL; AY045922; AAK76596.1; -; mRNA.
DR EMBL; AY079365; AAL85096.1; -; mRNA.
DR RefSeq; NP_001078150.1; NM_001084681.1. [Q94AM9-1]
DR RefSeq; NP_001078151.1; NM_001084682.1. [Q94AM9-1]
DR RefSeq; NP_566471.1; NM_112255.4. [Q94AM9-1]
DR AlphaFoldDB; Q94AM9; -.
DR BioGRID; 5949; 4.
DR IntAct; Q94AM9; 4.
DR STRING; 3702.AT3G14010.1; -.
DR iPTMnet; Q94AM9; -.
DR PaxDb; Q94AM9; -.
DR PRIDE; Q94AM9; -.
DR ProteomicsDB; 246845; -. [Q94AM9-1]
DR EnsemblPlants; AT3G14010.1; AT3G14010.1; AT3G14010. [Q94AM9-1]
DR EnsemblPlants; AT3G14010.2; AT3G14010.2; AT3G14010. [Q94AM9-1]
DR EnsemblPlants; AT3G14010.3; AT3G14010.3; AT3G14010. [Q94AM9-1]
DR GeneID; 820615; -.
DR Gramene; AT3G14010.1; AT3G14010.1; AT3G14010. [Q94AM9-1]
DR Gramene; AT3G14010.2; AT3G14010.2; AT3G14010. [Q94AM9-1]
DR Gramene; AT3G14010.3; AT3G14010.3; AT3G14010. [Q94AM9-1]
DR KEGG; ath:AT3G14010; -.
DR Araport; AT3G14010; -.
DR TAIR; locus:2088222; AT3G14010.
DR eggNOG; KOG2375; Eukaryota.
DR HOGENOM; CLU_022637_0_0_1; -.
DR InParanoid; Q94AM9; -.
DR PhylomeDB; Q94AM9; -.
DR PRO; PR:Q94AM9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q94AM9; baseline and differential.
DR Genevisible; Q94AM9; AT.
DR GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0034063; P:stress granule assembly; IBA:GO_Central.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR045117; ATXN2-like.
DR InterPro; IPR009604; LsmAD_domain.
DR InterPro; IPR025852; SM_dom_ATX.
DR PANTHER; PTHR12854; PTHR12854; 1.
DR Pfam; PF06741; LsmAD; 1.
DR Pfam; PF07145; PAM2; 1.
DR Pfam; PF14438; SM-ATX; 1.
DR SMART; SM01272; LsmAD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..595
FT /note="Polyadenylate-binding protein-interacting protein 4"
FT /id="PRO_0000428895"
FT REGION 302..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 466..474
FT /note="PAM2-like 1; degenerate"
FT MOTIF 475..485
FT /note="PAM2-like 2"
FT COMPBIAS 329..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 65709 MW; 23D27520F2A2B7CC CRC64;
MSIPQSKSSS NGFPLKRGET EEVLHKTNTS NTVFNGEAGS LKRLSLDRLV YFTTCKIGHH
VEVHLRNGSV YTGIFHAANV EKDFGIILKM ACLIKDGTLR GHKSRSEFVR KPPSKTFIIP
ADELVQVIAK DLSVSSNNMS NAVQGEKPSE LLTDSSISQS YHVDRERQLQ RWVPDETIPH
GADLENVFDN PWNRKWNQFE VNKSLFGVKS TFDEDLYTTR LERGPQTKQL EEHAQKIARE
IEAETTRDIH VAEERGLQLN ENFDFDEEAR YSSVRPVTGF GDSGFDLEDN ALLDTCNDLT
FGGSSTSDGQ KPASSGKGCE ELRVSGDSQS SRKNKNVDQS CSTSKQQSKD FPAAGSNISE
SQLDEQRRKN NEEVSHNNRS AEESTSGHGD IKEGAKSGGG ASSVSKAVTE REREASQVSS
KTKSESSFGQ SASRSSESRP GPSTSSRPGL SPSSSIGSMA SSEKSTLNPN AKEFKLNPKA
KSFKPLQSAA APPQSPIADA SFYYPGPSHV PVQQMPGMPP VNYGLPPYPG NQPQMMYHPQ
AYYHPNGQPQ YPQQQMIPGQ QQQQMIPGQQ HPRPVYYMHP PPYPQDMPYH NKGRE
