CIDA1_BACAN
ID CIDA1_BACAN Reviewed; 121 AA.
AC Q81Y27; Q6HVC5; Q6KPJ3;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Holin-like protein CidA 1;
GN Name=cidA1; OrderedLocusNames=BA_3730, GBAA_3730, BAS3458;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Increases the activity of extracellular murein hydrolases
CC possibly by mediating their export via hole formation. Inhibited by the
CC antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB
CC products probably inhibit the function of the CidA protein. When a cell
CC is stressed by the addition of antibiotics or by other factors in the
CC environment, CidA possibly oligomerizes within the bacterial cell
CC membrane, creating lesions that disrupt the proton motive force, which
CC in turn results in loss of cell viability. These lesions are also
CC hypothesized to regulate the subsequent cell lysis by either allowing
CC the murein hydrolases access to the cell wall substrate and/or
CC regulating their activity by a possible change in the cell wall pH that
CC results from loss of membrane potential (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CidA/LrgA family. CidA subfamily.
CC {ECO:0000305}.
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DR EMBL; AE016879; AAP27479.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT32842.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT55764.1; -; Genomic_DNA.
DR RefSeq; NP_845993.1; NC_003997.3.
DR RefSeq; WP_000872358.1; NZ_WXXJ01000029.1.
DR RefSeq; YP_029713.1; NC_005945.1.
DR AlphaFoldDB; Q81Y27; -.
DR SMR; Q81Y27; -.
DR STRING; 260799.BAS3458; -.
DR EnsemblBacteria; AAP27479; AAP27479; BA_3730.
DR EnsemblBacteria; AAT32842; AAT32842; GBAA_3730.
DR GeneID; 45023449; -.
DR KEGG; ban:BA_3730; -.
DR KEGG; bar:GBAA_3730; -.
DR KEGG; bat:BAS3458; -.
DR PATRIC; fig|198094.11.peg.3700; -.
DR eggNOG; COG1380; Bacteria.
DR HOGENOM; CLU_113736_3_2_9; -.
DR OMA; NWVRAGA; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01143; CidA; 1.
DR InterPro; IPR023760; Holin-like_CidA.
DR InterPro; IPR005538; LrgA/CidA.
DR PANTHER; PTHR33931; PTHR33931; 1.
DR Pfam; PF03788; LrgA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytolysis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..121
FT /note="Holin-like protein CidA 1"
FT /id="PRO_0000213173"
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 121 AA; 13749 MW; 850ADBC2867B6EEC CRC64;
MKWWKLSGQI LLLFCFAWTG EWIAKQAHLP IPGSIIGIFL LLISLKFNLV KKEWIQDGAD
FLLKELILFF IPSAVAVIRY KDTLSQYGID LILIIMISTL CVTLVTGLLT ELLLKRKGSV
Q