CIDA_BACLD
ID CIDA_BACLD Reviewed; 128 AA.
AC Q65DJ4; Q62P14;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Holin-like protein CidA {ECO:0000255|HAMAP-Rule:MF_01143};
GN Name=cidA {ECO:0000255|HAMAP-Rule:MF_01143};
GN OrderedLocusNames=BLi04057, BL03941;
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15383718; DOI=10.1159/000079829;
RA Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT with great industrial potential.";
RL J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- FUNCTION: Increases the activity of extracellular murein hydrolases
CC possibly by mediating their export via hole formation. Inhibited by the
CC antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB
CC products probably inhibit the function of the CidA protein. When a cell
CC is stressed by the addition of antibiotics or by other factors in the
CC environment, CidA possibly oligomerizes within the bacterial cell
CC membrane, creating lesions that disrupt the proton motive force, which
CC in turn results in loss of cell viability. These lesions are also
CC hypothesized to regulate the subsequent cell lysis by either allowing
CC the murein hydrolases access to the cell wall substrate and/or
CC regulating their activity by a possible change in the cell wall pH that
CC results from loss of membrane potential. {ECO:0000255|HAMAP-
CC Rule:MF_01143}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01143};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01143}.
CC -!- SIMILARITY: Belongs to the CidA/LrgA family. CidA subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01143}.
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DR EMBL; CP000002; AAU25497.1; -; Genomic_DNA.
DR EMBL; AE017333; AAU42870.1; -; Genomic_DNA.
DR RefSeq; WP_003186233.1; NC_006322.1.
DR AlphaFoldDB; Q65DJ4; -.
DR SMR; Q65DJ4; -.
DR STRING; 279010.BL03941; -.
DR EnsemblBacteria; AAU25497; AAU25497; BL03941.
DR GeneID; 66214000; -.
DR KEGG; bld:BLi04057; -.
DR KEGG; bli:BL03941; -.
DR eggNOG; COG1380; Bacteria.
DR HOGENOM; CLU_113736_3_2_9; -.
DR OMA; NWVRAGA; -.
DR OrthoDB; 1846131at2; -.
DR BioCyc; BLIC279010:BLI_RS19945-MON; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01143; CidA; 1.
DR InterPro; IPR023760; Holin-like_CidA.
DR InterPro; IPR005538; LrgA/CidA.
DR PANTHER; PTHR33931; PTHR33931; 1.
DR Pfam; PF03788; LrgA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytolysis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..128
FT /note="Holin-like protein CidA"
FT /id="PRO_1000065449"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01143"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01143"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01143"
SQ SEQUENCE 128 AA; 14223 MW; 9D2747DC557B35EE CRC64;
MKTFIKGLGQ VALLFLFARF MNLIVEVLHI NIPGSILGII VIFALLHFKI IKLEWIEIGA
LWLLAELLLF FVPSAVGIMN YGDILAEFGT SIILVVLIST FVVMVSTGML TQLIAKRKER
KKTCSSDA