ID   ACE_VIBCH               Reviewed;          96 AA.
AC   P38441; Q9KS10;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Accessory cholera enterotoxin;
DE            Short=Ace;
GN   Name=ace; OrderedLocusNames=VC_1459;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 55056 / El Tor Ogawa E7946;
RX   PubMed=8389476; DOI=10.1073/pnas.90.11.5267;
RA   Trucksis M., Galen J.E., Michalski J., Fasano A., Kaper J.B.;
RT   "Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae
RT   virulence cassette.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:5267-5271(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KNIH002;
RA   Shin H.J., Park Y.C., Kim Y.C.;
RT   "Cloning and nucleotide sequence analysis of the virulence gene cassette
RT   from Vibrio cholerae KNIH002 isolated in Korea.";
RL   Misainmurhag Hoiji 35:205-210(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=El Tor 86015 / Serotype O1;
RA   Kan B., Liu Y.Q., Qi G.M., Gao S.Y.;
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Increases short-circuit current in rabbit ileal tissue
CC       mounted in Ussing chambers, by increasing the potential difference.
CC       Cultures of V.cholerae containing the cloned ace gene cause fluid
CC       secretion in ligated rabbit ileal loops.
CC   -!- SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1, Met-3 or Met-4 is the
CC       initiator. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF94616.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z22569; CAA80292.1; -; Genomic_DNA.
DR   EMBL; AF175708; AAD51357.1; -; Genomic_DNA.
DR   EMBL; AF220606; AAF29546.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF94616.1; ALT_INIT; Genomic_DNA.
DR   PIR; C82197; C82197.
DR   PIR; S36030; S36030.
DR   RefSeq; NP_231102.1; NC_002505.1.
DR   AlphaFoldDB; P38441; -.
DR   STRING; 243277.VC_1459; -.
DR   DNASU; 2613965; -.
DR   EnsemblBacteria; AAF94616; AAF94616; VC_1459.
DR   KEGG; vch:VC_1459; -.
DR   PATRIC; fig|243277.26.peg.1389; -.
DR   eggNOG; ENOG5031PSX; Bacteria.
DR   HOGENOM; CLU_186216_0_0_6; -.
DR   OMA; DYIYSWF; -.
DR   PHI-base; PHI:706; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019670; DUF2523.
DR   Pfam; PF10734; DUF2523; 1.
PE   4: Predicted;
KW   Enterotoxin; Host cell membrane; Host membrane; Membrane;
KW   Reference proteome; Secreted; Toxin; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..96
FT                   /note="Accessory cholera enterotoxin"
FT                   /id="PRO_0000064435"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   96 AA;  11347 MW;  77316515B580134A CRC64;
     MLMMDTLYDW LIDGFTWLVI KLGIMWIESK IFVIQFFWEM SQKVIDMFTI YPLIQQAIDM
     LPPQYSGFLF FLGLDQALAI VLQALMTRFA LRALNL