CIDEB_HUMAN
ID CIDEB_HUMAN Reviewed; 219 AA.
AC Q9UHD4; D3DS73; Q546V8; Q9NNW9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 27-MAR-2002, sequence version 2.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Cell death activator CIDE-B;
DE AltName: Full=Cell death-inducing DFFA-like effector B;
GN Name=CIDEB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR OF 1-116, AND INTERACTION WITH
RP DFFA AND DFFB.
RX PubMed=10619428; DOI=10.1016/s0092-8674(00)81672-4;
RA Lugovskoy A.A., Zhou P., Chou J.J., McCarty J.S., Li P., Wagner G.;
RT "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-
RT N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.";
RL Cell 99:747-755(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9564035; DOI=10.1093/emboj/17.9.2526;
RA Inohara N., Koseki T., Chen S., Wu X., Nunez G.;
RT "CIDE, a novel family of cell death activators with homology to the 45 kDa
RT subunit of the DNA fragmentation factor.";
RL EMBO J. 17:2526-2533(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Liang L., Zhao M., Li T.;
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ileal mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=12429024; DOI=10.1042/bj20020656;
RA Liang L., Zhao M., Xu Z., Yokoyama K.K., Li T.;
RT "Molecular cloning and characterization of CIDE-3, a novel member of the
RT cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector
RT family.";
RL Biochem. J. 370:195-203(2003).
RN [8]
RP INTERACTION WITH HCV NON-STRUCTURAL PROTEIN 5A (MICROBIAL INFECTION), AND
RP FUNCTION (MICROBIAL INFECTION).
RX PubMed=27282740; DOI=10.1038/srep27778;
RA Cai H., Yao W., Li L., Li X., Hu L., Mai R., Peng T.;
RT "Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of
RT Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A.";
RL Sci. Rep. 6:27778-27778(2016).
CC -!- FUNCTION: Activates apoptosis.
CC -!- FUNCTION: (Microbial infection) Involved in Hepatatis C virus (HCV)
CC assembly and required for HCV entry into hepatocytes.
CC {ECO:0000269|PubMed:27282740}.
CC -!- SUBUNIT: Inhibited by DFFB. Interacts with DFFA and DFFB.
CC {ECO:0000269|PubMed:10619428}.
CC -!- SUBUNIT: (Microbial infection) Interacts (via N-terminus) with HCV non-
CC structural protein 5A (via N-terminus); this interaction seems to
CC regulate the association of HCV particles with ApoE.
CC {ECO:0000269|PubMed:27282740}.
CC -!- INTERACTION:
CC Q9UHD4; O95870: ABHD16A; NbExp=3; IntAct=EBI-7062247, EBI-348517;
CC Q9UHD4; Q8WV93: AFG1L; NbExp=3; IntAct=EBI-7062247, EBI-2865743;
CC Q9UHD4; P02654: APOC1; NbExp=3; IntAct=EBI-7062247, EBI-1220105;
CC Q9UHD4; Q9NVJ2: ARL8B; NbExp=3; IntAct=EBI-7062247, EBI-718376;
CC Q9UHD4; P56385: ATP5ME; NbExp=3; IntAct=EBI-7062247, EBI-2270000;
CC Q9UHD4; P56378-2: ATP5MPL; NbExp=3; IntAct=EBI-7062247, EBI-17870477;
CC Q9UHD4; Q92843: BCL2L2; NbExp=3; IntAct=EBI-7062247, EBI-707714;
CC Q9UHD4; Q86SI9: C5orf38; NbExp=3; IntAct=EBI-7062247, EBI-17872065;
CC Q9UHD4; O75155: CAND2; NbExp=3; IntAct=EBI-7062247, EBI-5656182;
CC Q9UHD4; Q9UHD4: CIDEB; NbExp=7; IntAct=EBI-7062247, EBI-7062247;
CC Q9UHD4; P35523: CLCN1; NbExp=3; IntAct=EBI-7062247, EBI-10206780;
CC Q9UHD4; P30085-3: CMPK1; NbExp=3; IntAct=EBI-7062247, EBI-23373346;
CC Q9UHD4; Q03692: COL10A1; NbExp=3; IntAct=EBI-7062247, EBI-2528309;
CC Q9UHD4; P27658: COL8A1; NbExp=3; IntAct=EBI-7062247, EBI-747133;
CC Q9UHD4; P15954: COX7C; NbExp=3; IntAct=EBI-7062247, EBI-2606678;
CC Q9UHD4; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-7062247, EBI-3923585;
CC Q9UHD4; Q96EY1: DNAJA3; NbExp=3; IntAct=EBI-7062247, EBI-356767;
CC Q9UHD4; Q96MZ4: FAM218A; NbExp=3; IntAct=EBI-7062247, EBI-10291578;
CC Q9UHD4; Q14318: FKBP8; NbExp=3; IntAct=EBI-7062247, EBI-724839;
CC Q9UHD4; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-7062247, EBI-11961494;
CC Q9UHD4; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-7062247, EBI-714482;
CC Q9UHD4; P23434: GCSH; NbExp=3; IntAct=EBI-7062247, EBI-715444;
CC Q9UHD4; P16520-2: GNB3; NbExp=3; IntAct=EBI-7062247, EBI-17871073;
CC Q9UHD4; Q9HCL2: GPAM; NbExp=3; IntAct=EBI-7062247, EBI-7600236;
CC Q9UHD4; Q99525: H4C7; NbExp=3; IntAct=EBI-7062247, EBI-10294329;
CC Q9UHD4; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-7062247, EBI-11956675;
CC Q9UHD4; P53701: HCCS; NbExp=3; IntAct=EBI-7062247, EBI-10763431;
CC Q9UHD4; A8MV81: HIGD1C; NbExp=3; IntAct=EBI-7062247, EBI-12809676;
CC Q9UHD4; P42858: HTT; NbExp=3; IntAct=EBI-7062247, EBI-466029;
CC Q9UHD4; P13473-2: LAMP2; NbExp=3; IntAct=EBI-7062247, EBI-21591415;
CC Q9UHD4; Q5EB52: MEST; NbExp=3; IntAct=EBI-7062247, EBI-1050204;
CC Q9UHD4; Q5TGZ0: MICOS10; NbExp=3; IntAct=EBI-7062247, EBI-12886442;
CC Q9UHD4; O95563: MPC2; NbExp=3; IntAct=EBI-7062247, EBI-719403;
CC Q9UHD4; Q9P0J6: MRPL36; NbExp=3; IntAct=EBI-7062247, EBI-2115401;
CC Q9UHD4; Q9BQC6: MRPL57; NbExp=3; IntAct=EBI-7062247, EBI-1055359;
CC Q9UHD4; Q7Z6M4: MTERF4; NbExp=3; IntAct=EBI-7062247, EBI-948435;
CC Q9UHD4; Q9Y3Q0: NAALAD2; NbExp=3; IntAct=EBI-7062247, EBI-2863682;
CC Q9UHD4; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-7062247, EBI-11978907;
CC Q9UHD4; Q9UMS0: NFU1; NbExp=3; IntAct=EBI-7062247, EBI-725252;
CC Q9UHD4; O00746: NME4; NbExp=3; IntAct=EBI-7062247, EBI-744871;
CC Q9UHD4; Q96AL5: PBX3; NbExp=3; IntAct=EBI-7062247, EBI-741171;
CC Q9UHD4; O00330: PDHX; NbExp=3; IntAct=EBI-7062247, EBI-751566;
CC Q9UHD4; Q96LB9: PGLYRP3; NbExp=3; IntAct=EBI-7062247, EBI-12339509;
CC Q9UHD4; Q9UG56-2: PISD; NbExp=3; IntAct=EBI-7062247, EBI-17870882;
CC Q9UHD4; P30405: PPIF; NbExp=3; IntAct=EBI-7062247, EBI-5544229;
CC Q9UHD4; O60895: RAMP2; NbExp=3; IntAct=EBI-7062247, EBI-9009040;
CC Q9UHD4; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-7062247, EBI-17589229;
CC Q9UHD4; P60602: ROMO1; NbExp=3; IntAct=EBI-7062247, EBI-11909831;
CC Q9UHD4; Q14D33: RTP5; NbExp=3; IntAct=EBI-7062247, EBI-10217913;
CC Q9UHD4; P0DJI9: SAA2; NbExp=3; IntAct=EBI-7062247, EBI-6677144;
CC Q9UHD4; P35542: SAA4; NbExp=3; IntAct=EBI-7062247, EBI-750242;
CC Q9UHD4; Q9Y6B6: SAR1B; NbExp=3; IntAct=EBI-7062247, EBI-4290665;
CC Q9UHD4; O75880: SCO1; NbExp=3; IntAct=EBI-7062247, EBI-6656171;
CC Q9UHD4; O43819: SCO2; NbExp=3; IntAct=EBI-7062247, EBI-357012;
CC Q9UHD4; A6NFY7: SDHAF1; NbExp=3; IntAct=EBI-7062247, EBI-12011488;
CC Q9UHD4; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-7062247, EBI-355861;
CC Q9UHD4; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-7062247, EBI-2623095;
CC Q9UHD4; Q92922: SMARCC1; NbExp=3; IntAct=EBI-7062247, EBI-355653;
CC Q9UHD4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-7062247, EBI-742688;
CC Q9UHD4; Q9UL54: TAOK2; NbExp=3; IntAct=EBI-7062247, EBI-352832;
CC Q9UHD4; Q13207: TBX2; NbExp=3; IntAct=EBI-7062247, EBI-2853051;
CC Q9UHD4; Q53QW1: TEX44; NbExp=5; IntAct=EBI-7062247, EBI-10278496;
CC Q9UHD4; P07204: THBD; NbExp=3; IntAct=EBI-7062247, EBI-941422;
CC Q9UHD4; O60830: TIMM17B; NbExp=5; IntAct=EBI-7062247, EBI-2372529;
CC Q9UHD4; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-7062247, EBI-8638294;
CC Q9UHD4; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-7062247, EBI-17249488;
CC Q9UHD4; Q2NL82: TSR1; NbExp=3; IntAct=EBI-7062247, EBI-358058;
CC Q9UHD4; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-7062247, EBI-12068150;
CC Q9UHD4; PRO_0000037572 [P27958]; Xeno; NbExp=6; IntAct=EBI-7062247, EBI-6919131;
CC -!- TISSUE SPECIFICITY: Highly expressed in liver and small intestine and,
CC at lower levels, in colon, kidney and spleen.
CC {ECO:0000269|PubMed:12429024}.
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DR EMBL; AF190901; AAF23324.1; -; mRNA.
DR EMBL; AF218586; AAF27658.1; -; mRNA.
DR EMBL; AF544398; AAN37907.1; -; mRNA.
DR EMBL; AK000387; BAA91132.1; -; mRNA.
DR EMBL; CH471078; EAW66031.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66032.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66033.1; -; Genomic_DNA.
DR EMBL; BC035970; AAH35970.1; -; mRNA.
DR CCDS; CCDS32056.1; -.
DR RefSeq; NP_001305736.1; NM_001318807.1.
DR RefSeq; NP_055245.2; NM_014430.2.
DR RefSeq; XP_011534961.1; XM_011536659.2.
DR RefSeq; XP_016876710.1; XM_017021221.1.
DR PDB; 1D4B; NMR; -; A=1-116.
DR PDBsum; 1D4B; -.
DR AlphaFoldDB; Q9UHD4; -.
DR BMRB; Q9UHD4; -.
DR SMR; Q9UHD4; -.
DR BioGRID; 118027; 78.
DR IntAct; Q9UHD4; 69.
DR STRING; 9606.ENSP00000337731; -.
DR iPTMnet; Q9UHD4; -.
DR PhosphoSitePlus; Q9UHD4; -.
DR BioMuta; CIDEB; -.
DR DMDM; 20141283; -.
DR MassIVE; Q9UHD4; -.
DR PaxDb; Q9UHD4; -.
DR PeptideAtlas; Q9UHD4; -.
DR PRIDE; Q9UHD4; -.
DR ProteomicsDB; 84324; -.
DR Antibodypedia; 9150; 346 antibodies from 35 providers.
DR DNASU; 27141; -.
DR Ensembl; ENST00000258807.5; ENSP00000258807.5; ENSG00000136305.12.
DR Ensembl; ENST00000336557.9; ENSP00000337731.5; ENSG00000136305.12.
DR Ensembl; ENST00000554411.6; ENSP00000451089.1; ENSG00000136305.12.
DR Ensembl; ENST00000642223.1; ENSP00000493738.1; ENSG00000285199.1.
DR Ensembl; ENST00000644519.1; ENSP00000494868.1; ENSG00000285199.1.
DR Ensembl; ENST00000644672.1; ENSP00000495235.1; ENSG00000285199.1.
DR GeneID; 27141; -.
DR KEGG; hsa:27141; -.
DR MANE-Select; ENST00000554411.6; ENSP00000451089.1; NM_001393339.1; NP_001380268.1.
DR UCSC; uc001won.4; human.
DR CTD; 27141; -.
DR DisGeNET; 27141; -.
DR GeneCards; CIDEB; -.
DR HGNC; HGNC:1977; CIDEB.
DR HPA; ENSG00000136305; Tissue enhanced (liver).
DR MIM; 604441; gene.
DR neXtProt; NX_Q9UHD4; -.
DR OpenTargets; ENSG00000136305; -.
DR PharmGKB; PA26515; -.
DR VEuPathDB; HostDB:ENSG00000136305; -.
DR eggNOG; ENOG502RUS7; Eukaryota.
DR GeneTree; ENSGT00390000018596; -.
DR HOGENOM; CLU_090011_0_0_1; -.
DR InParanoid; Q9UHD4; -.
DR OMA; RICCNRR; -.
DR OrthoDB; 1421916at2759; -.
DR PhylomeDB; Q9UHD4; -.
DR TreeFam; TF334321; -.
DR PathwayCommons; Q9UHD4; -.
DR SignaLink; Q9UHD4; -.
DR BioGRID-ORCS; 27141; 17 hits in 1017 CRISPR screens.
DR ChiTaRS; CIDEB; human.
DR EvolutionaryTrace; Q9UHD4; -.
DR GenomeRNAi; 27141; -.
DR Pharos; Q9UHD4; Tbio.
DR PRO; PR:Q9UHD4; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9UHD4; protein.
DR Bgee; ENSG00000136305; Expressed in right lobe of liver and 99 other tissues.
DR ExpressionAtlas; Q9UHD4; baseline and differential.
DR Genevisible; Q9UHD4; HS.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:AgBase.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IDA:AgBase.
DR GO; GO:0006915; P:apoptotic process; IDA:MGI.
DR GO; GO:0038183; P:bile acid signaling pathway; IEA:Ensembl.
DR GO; GO:0097194; P:execution phase of apoptosis; ISS:BHF-UCL.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; TAS:ProtInc.
DR GO; GO:0010942; P:positive regulation of cell death; IDA:AgBase.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IDA:AgBase.
DR GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IEA:Ensembl.
DR InterPro; IPR003508; CIDE-N_dom.
DR Pfam; PF02017; CIDE-N; 1.
DR SMART; SM00266; CAD; 1.
DR PROSITE; PS51135; CIDE_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Apoptosis; Host-virus interaction; Reference proteome.
FT CHAIN 1..219
FT /note="Cell death activator CIDE-B"
FT /id="PRO_0000144720"
FT DOMAIN 34..110
FT /note="CIDE-N"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00447"
FT CONFLICT 120
FT /note="L -> P (in Ref. 1; AAF23324)"
FT /evidence="ECO:0000305"
FT CONFLICT 124
FT /note="R -> S (in Ref. 1; AAF23324)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="A -> G (in Ref. 1; AAF23324)"
FT /evidence="ECO:0000305"
FT STRAND 9..12
FT /evidence="ECO:0007829|PDB:1D4B"
FT STRAND 36..41
FT /evidence="ECO:0007829|PDB:1D4B"
FT STRAND 43..46
FT /evidence="ECO:0007829|PDB:1D4B"
FT STRAND 48..53
FT /evidence="ECO:0007829|PDB:1D4B"
FT HELIX 59..67
FT /evidence="ECO:0007829|PDB:1D4B"
FT STRAND 74..77
FT /evidence="ECO:0007829|PDB:1D4B"
FT TURN 78..81
FT /evidence="ECO:0007829|PDB:1D4B"
FT STRAND 82..84
FT /evidence="ECO:0007829|PDB:1D4B"
FT HELIX 88..92
FT /evidence="ECO:0007829|PDB:1D4B"
FT STRAND 93..95
FT /evidence="ECO:0007829|PDB:1D4B"
SQ SEQUENCE 219 AA; 24678 MW; E0B4E5EF1F7C912D CRC64;
MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG LTAATRQELL
AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM VLQSGQSWSP TRSGVLSYGL
GRERPKHSKD IARFTFDVYK QNPRDLFGSL NVKATFYGLY SMSCDFQGLG PKKVLRELLR
WTSTLLQGLG HMLLGISSTL RHAVEGAEQW QQKGRLHSY
