ID   CIDEB_MOUSE             Reviewed;         219 AA.
AC   O70303; Q91X39;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 2.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Cell death activator CIDE-B;
DE   AltName: Full=Cell death-inducing DFFA-like effector B;
GN   Name=Cideb;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9564035; DOI=10.1093/emboj/17.9.2526;
RA   Inohara N., Koseki T., Chen S., Wu X., Nunez G.;
RT   "CIDE, a novel family of cell death activators with homology to the 45 kDa
RT   subunit of the DNA fragmentation factor.";
RL   EMBO J. 17:2526-2533(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Activates apoptosis.
CC   -!- SUBUNIT: Inhibited by DFFB. Interacts with DFFA and DFFB (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; AF041377; AAC34986.1; -; mRNA.
DR   EMBL; BC012664; AAH12664.1; -; mRNA.
DR   EMBL; BC046340; AAH46340.1; -; mRNA.
DR   CCDS; CCDS27127.1; -.
DR   RefSeq; NP_034024.2; NM_009894.3.
DR   AlphaFoldDB; O70303; -.
DR   SMR; O70303; -.
DR   STRING; 10090.ENSMUSP00000001497; -.
DR   iPTMnet; O70303; -.
DR   PhosphoSitePlus; O70303; -.
DR   MaxQB; O70303; -.
DR   PaxDb; O70303; -.
DR   PRIDE; O70303; -.
DR   ProteomicsDB; 283556; -.
DR   Antibodypedia; 9150; 346 antibodies from 35 providers.
DR   DNASU; 12684; -.
DR   Ensembl; ENSMUST00000001497; ENSMUSP00000001497; ENSMUSG00000022219.
DR   GeneID; 12684; -.
DR   KEGG; mmu:12684; -.
DR   UCSC; uc007uap.2; mouse.
DR   CTD; 27141; -.
DR   MGI; MGI:1270844; Cideb.
DR   VEuPathDB; HostDB:ENSMUSG00000022219; -.
DR   eggNOG; ENOG502RUS7; Eukaryota.
DR   GeneTree; ENSGT00390000018596; -.
DR   HOGENOM; CLU_090011_0_0_1; -.
DR   InParanoid; O70303; -.
DR   OMA; RICCNRR; -.
DR   OrthoDB; 1421916at2759; -.
DR   PhylomeDB; O70303; -.
DR   TreeFam; TF334321; -.
DR   BioGRID-ORCS; 12684; 4 hits in 72 CRISPR screens.
DR   ChiTaRS; Cideb; mouse.
DR   PRO; PR:O70303; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; O70303; protein.
DR   Bgee; ENSMUSG00000022219; Expressed in small intestine Peyer's patch and 99 other tissues.
DR   Genevisible; O70303; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; ISO:MGI.
DR   GO; GO:0006915; P:apoptotic process; ISO:MGI.
DR   GO; GO:0097194; P:execution phase of apoptosis; IDA:BHF-UCL.
DR   GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISO:MGI.
DR   GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR   InterPro; IPR003508; CIDE-N_dom.
DR   Pfam; PF02017; CIDE-N; 1.
DR   SMART; SM00266; CAD; 1.
DR   PROSITE; PS51135; CIDE_N; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..219
FT                   /note="Cell death activator CIDE-B"
FT                   /id="PRO_0000144721"
FT   DOMAIN          34..110
FT                   /note="CIDE-N"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00447"
FT   MOD_RES         18
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:17242355"
FT   CONFLICT        180
FT                   /note="W -> G (in Ref. 1; AAC34986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        184
FT                   /note="L -> Q (in Ref. 1; AAC34986)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   219 AA;  24800 MW;  8915FB3CC5FE7721 CRC64;
     MEYLSAFNPN GLLRSVSTVS SELSRRVWNS APPPQRPFRV CDHKRTVRKG LTAASLQELL
     DKVLETLLLR GVLTLVLEED GTAVDSEDFF QLLEDDTCLM VLEQGQSWSP KSGMLSYGLG
     REKPKHSKDI ARITFDVYKQ NPRDLFGSLN VKATFYGLYS MSCDFQGVGP KRVLRELLRW
     TSSLLQGLGH MLLGISSTLR HVVEGADRWQ WHGQRHLHS