ID   CIF1_SCHPO              Reviewed;         320 AA.
AC   O59792;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Calnexin-independence factor 1;
GN   Name=cif1; ORFNames=SPCC364.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19351719; DOI=10.1242/jcs.040949;
RA   Beauregard P.B., Guerin R., Turcotte C., Lindquist S., Rokeach L.A.;
RT   "A nucleolar protein allows viability in the absence of the essential ER-
RT   residing molecular chaperone calnexin.";
RL   J. Cell Sci. 122:1342-1351(2009).
CC   -!- FUNCTION: Induces a stably inheritable state of calnexin independence
CC       called the Cin state when overexpressed. {ECO:0000269|PubMed:19351719}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372,
CC       ECO:0000269|PubMed:19351719}.
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DR   EMBL; CU329672; CAA18283.1; -; Genomic_DNA.
DR   PIR; T41335; T41335.
DR   RefSeq; NP_587843.1; NM_001022836.2.
DR   AlphaFoldDB; O59792; -.
DR   SMR; O59792; -.
DR   BioGRID; 276097; 4.
DR   STRING; 4896.SPCC364.01.1; -.
DR   MaxQB; O59792; -.
DR   PaxDb; O59792; -.
DR   PRIDE; O59792; -.
DR   EnsemblFungi; SPCC364.01.1; SPCC364.01.1:pep; SPCC364.01.
DR   GeneID; 2539535; -.
DR   KEGG; spo:SPCC364.01; -.
DR   PomBase; SPCC364.01; cif1.
DR   VEuPathDB; FungiDB:SPCC364.01; -.
DR   HOGENOM; CLU_874817_0_0_1; -.
DR   OMA; LHQWYSL; -.
DR   PRO; PR:O59792; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005730; C:nucleolus; IDA:PomBase.
DR   GO; GO:0006984; P:ER-nucleus signaling pathway; IGI:PomBase.
PE   4: Predicted;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..320
FT                   /note="Calnexin-independence factor 1"
FT                   /id="PRO_0000303995"
FT   REGION          16..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   320 AA;  36018 MW;  99C1C33677D0AD86 CRC64;
     MSEEIITESI VKNFGSAETS VGEKQPKRKR SEVRAEKLKA RKLQKAAEIV QKQKENRKIL
     KDVSLKRLSK SLDRSLPSEN TIDQISFNHA MSEEDASGYQ IGDKHKNLLL YKLSSSSGSV
     FTENLYSTIQ EFLSAQKVDI ADSKNTYVFG STFDKKSHAL VKTSDSVRSL KYGSFVKACA
     PLFRFASGII KAHAPHFHQA LLKLELAPSA LRFGVFPNFS LQSVSNGYMS MESNFSSIKY
     GFVVIIIVGE LNDVELKIPA ISHSLKLKDG SILVLRSSLL HQWYSLPKQS ILYEIRLFAM
     SSLWHYEKNK SIKIAKKDDI