ID   CILA_HAEIN              Reviewed;         500 AA.
AC   P44459;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Citrate lyase alpha chain;
DE            Short=Citrase alpha chain;
DE            EC=4.1.3.6;
DE   AltName: Full=Citrate (pro-3S)-lyase alpha chain;
DE   AltName: Full=Citrate CoA-transferase subunit;
DE            EC=2.8.3.10;
GN   Name=citF; OrderedLocusNames=HI_0022;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Represents a citrate:acetyl-ACP transferase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=citrate = acetate + oxaloacetate; Xref=Rhea:RHEA:10760,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089; EC=4.1.3.6;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + citrate = (3S)-citryl-CoA + acetate;
CC         Xref=Rhea:RHEA:19405, ChEBI:CHEBI:16947, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:57321; EC=2.8.3.10;
CC   -!- SUBUNIT: Oligomer with a subunit composition of (alpha,beta,gamma)6.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
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DR   EMBL; L42023; AAC21700.1; -; Genomic_DNA.
DR   PIR; C64043; C64043.
DR   RefSeq; NP_438195.1; NC_000907.1.
DR   RefSeq; WP_005663293.1; NC_000907.1.
DR   AlphaFoldDB; P44459; -.
DR   SMR; P44459; -.
DR   STRING; 71421.HI_0022; -.
DR   EnsemblBacteria; AAC21700; AAC21700; HI_0022.
DR   KEGG; hin:HI_0022; -.
DR   PATRIC; fig|71421.8.peg.22; -.
DR   eggNOG; COG3051; Bacteria.
DR   HOGENOM; CLU_046521_2_0_6; -.
DR   OMA; GHCDVAA; -.
DR   PhylomeDB; P44459; -.
DR   BioCyc; HINF71421:G1GJ1-22-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009346; C:ATP-independent citrate lyase complex; IEA:InterPro.
DR   GO; GO:0008815; F:citrate (pro-3S)-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008814; F:citrate CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   InterPro; IPR006472; Citrate_lyase_asu.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR40596; PTHR40596; 1.
DR   Pfam; PF04223; CitF; 1.
DR   PIRSF; PIRSF009451; Citrt_lyas_alpha; 1.
DR   SUPFAM; SSF100950; SSF100950; 2.
DR   TIGRFAMs; TIGR01584; citF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Reference proteome; Transferase.
FT   CHAIN           1..500
FT                   /note="Citrate lyase alpha chain"
FT                   /id="PRO_0000089753"
SQ   SEQUENCE   500 AA;  54134 MW;  F7D1EF303C446913 CRC64;
     MTTREQRIEK YHADRSVYQA VPKSESLSRT AKDRKLCTSL EEAIKRSGLK DGMTVSFHHA
     FRGGDFVVNM VMNKIAEMGF KNLTLASSSL IDSHFPIVEH IKNGVVTKIY SSGLRGELAE
     QISRGLLNEP VNIHSHGGRV HLVKSGELKI DVAFLGVPCC DTFGNANGFT GKSKCGSLGY
     ARVDAEYADK VVLLTEEFVE YPHHPISIAQ DQVDLIVQVE AVGDPKKIGG GATRMTTNPR
     ELLIARKCAE VIFASGYFKD GFSLQTGSGG AALAVTRFLE EKMRRENITA DFALGGITAS
     MVALHEAGLI KKLLDVQSFD SVAAESLARN PNHIEVSANQ YANYSSKGAS VERLDMVILS
     ALEIDTKFNV NVLTGSDGVI RGASGGHCDT AASAQVAIIV APLVRGRIPT VVENVITCVT
     PGENVDILVT DHGVAVNPKR PDLIEALSKT DIPLFTIEQL CERAYSITGK PKEIEFTNKP
     VAVVRYRDGS VIDTVYQVKD