CIN1_YEAST
ID CIN1_YEAST Reviewed; 1014 AA.
AC P40987; D6W344;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Chromosome instability protein 1;
GN Name=CIN1; OrderedLocusNames=YOR349W; ORFNames=O6350;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RA Hoyt M.;
RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 90843 / S288c / FY73;
RX PubMed=8948102;
RX DOI=10.1002/(sici)1097-0061(199611)12:14<1475::aid-yea32>3.0.co;2-v;
RA Purnelle B., Goffeau A.;
RT "Nucleotide sequence analysis of a 40 kb segment on the right arm of yeast
RT chromosome XV reveals 18 open reading frames including a new pyruvate
RT kinase and three homologues to chromosome I genes.";
RL Yeast 12:1475-1481(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Required for microtubule stability. Interacts with CIN4.
CC -!- MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z46420; CAA86556.1; -; Genomic_DNA.
DR EMBL; X95720; CAA65036.1; -; Genomic_DNA.
DR EMBL; Z75257; CAA99677.1; -; Genomic_DNA.
DR EMBL; Z75258; CAA99679.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA11110.1; -; Genomic_DNA.
DR PIR; S48235; S48235.
DR RefSeq; NP_014994.3; NM_001183769.3.
DR AlphaFoldDB; P40987; -.
DR BioGRID; 34734; 227.
DR DIP; DIP-5809N; -.
DR IntAct; P40987; 2.
DR MINT; P40987; -.
DR STRING; 4932.YOR349W; -.
DR iPTMnet; P40987; -.
DR MaxQB; P40987; -.
DR PaxDb; P40987; -.
DR PRIDE; P40987; -.
DR EnsemblFungi; YOR349W_mRNA; YOR349W; YOR349W.
DR GeneID; 854531; -.
DR KEGG; sce:YOR349W; -.
DR SGD; S000005876; CIN1.
DR VEuPathDB; FungiDB:YOR349W; -.
DR eggNOG; KOG1943; Eukaryota.
DR HOGENOM; CLU_288698_0_0_1; -.
DR InParanoid; P40987; -.
DR OMA; ATNFICW; -.
DR BioCyc; YEAST:G3O-33821-MON; -.
DR PRO; PR:P40987; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; P40987; protein.
DR GO; GO:0048487; F:beta-tubulin binding; ISS:SGD.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IGI:SGD.
DR GO; GO:0007021; P:tubulin complex assembly; IMP:SGD.
DR InterPro; IPR033162; TBCD.
DR PANTHER; PTHR12658; PTHR12658; 2.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..1014
FT /note="Chromosome instability protein 1"
FT /id="PRO_0000089761"
SQ SEQUENCE 1014 AA; 116648 MW; D0BE6141869F9EA5 CRC64;
MNNIRALLDS IQSGVQTVSP EKHQQTIAAI NKFQDDPALL DTILPRCVPL LTKSFFCMSQ
RDQKLVAELF YNLDKISHSK VLKSLDTSIF RLNEILNYLQ DRASPSSFSD VLCVYLNLSW
LSVILLSPYA FKDKFNKTLQ VSSRFENYPI CIPPINKIKA VLYFKNFTDA FDQLPEREQA
NVPFLNQFLK LFIQSSEKAN YYFSNENLRH LQQVALSNDG IKLLPKLFQI SFNHGSHDIL
DAIVEFFHDH LSSNSTDTRF QLAHSFAKIA KFLHQADPAS FIELIDYTIE NTVSLLQAPC
DSIDSNELHT SLLIIAEVAL AKILPIDLVD RVLTLIIPKT CHFQKSHFQI IKGHHIRDST
NFIIWSVIRS NRSNSLSPQV LQSLLSHLLI NAFFDPELII RYSSFAALQE LLGRSNKSLA
LNQNDIALIL QANWKDLPRS FEENSGLIRR LFNPENTSKS AVCVWKVFRD WSFNWNLLEN
LHLTTMKLNI DYNLVPLIKS KLSSPALLQE VLNKAGSSVT QNCQILYLYL KLFENDVNCP
KISEICIDIY QKKIKFQLTT QAKRQFNDNS PELFQIFVIL KYWQLTGQND FNQELFWKFV
DIVSPQKKLN LYNEFIPIIQ QIISQCVSLN YTRIVQLIKS DNELTCRSIC HMPDQEKMCS
LFFSQFPLLS PQSRSLLIGE LDHHWDVRIS LLPSNSYRKF RNIIINCLDD YTITQQGDVG
RLVRIQALKL MQSHPDFLSG DCDSINPKLT RLLAEPVPEI RKLSYQLLAS ATSQITVLSD
SSILNFRHKQ GLSEEFWKGY AVSAGAIHFT DSQLTSSIDS FIVYYRSLSP SQQLELCHDL
IRIIPSAKQI AESRIRDRNK DPLTGGMRFD TIKFTIHCVK FWTRIMESGL VVLHPNFNFQ
GVFAKFYNLH LLDCTTLRVS VIKFFPFLAI SCYHTMRENA DQKNLSNIIL KRLLVLVKRE
YAATKSKFMT DQNVALQGMF QIFLELGVTR QLQALQVACQ KHELANILES DITL
