ID   CINAL_ECOLI             Reviewed;         400 AA.
AC   P77808;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=NMN amidohydrolase-like protein YfaY;
GN   Name=yfaY; OrderedLocusNames=b2249, JW2243;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA   Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA   Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA   Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT   genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT   its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   LACK OF NMN AMIDOHYDROLASE FUNCTION.
RC   STRAIN=K12;
RX   PubMed=21953451; DOI=10.1074/jbc.m111.275818;
RA   Galeazzi L., Bocci P., Amici A., Brunetti L., Ruggieri S., Romine M.,
RA   Reed S., Osterman A.L., Rodionov D.A., Sorci L., Raffaelli N.;
RT   "Identification of nicotinamide mononucleotide deamidase of the bacterial
RT   pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase
RT   family.";
RL   J. Biol. Chem. 286:40365-40375(2011).
CC   -!- FUNCTION: Does not have nicotinamide-nucleotide (NMN) amidohydrolase
CC       activity.
CC   -!- SIMILARITY: Belongs to the CinA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00226}.
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DR   EMBL; U00096; AAC75309.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16073.1; -; Genomic_DNA.
DR   PIR; G64995; G64995.
DR   RefSeq; NP_416752.1; NC_000913.3.
DR   RefSeq; WP_000921621.1; NZ_LN832404.1.
DR   AlphaFoldDB; P77808; -.
DR   SMR; P77808; -.
DR   BioGRID; 4261213; 25.
DR   BioGRID; 849852; 1.
DR   DIP; DIP-9281N; -.
DR   IntAct; P77808; 6.
DR   STRING; 511145.b2249; -.
DR   jPOST; P77808; -.
DR   PaxDb; P77808; -.
DR   PRIDE; P77808; -.
DR   EnsemblBacteria; AAC75309; AAC75309; b2249.
DR   EnsemblBacteria; BAA16073; BAA16073; BAA16073.
DR   GeneID; 945478; -.
DR   KEGG; ecj:JW2243; -.
DR   KEGG; eco:b2249; -.
DR   PATRIC; fig|511145.12.peg.2340; -.
DR   EchoBASE; EB3840; -.
DR   eggNOG; COG1058; Bacteria.
DR   HOGENOM; CLU_030805_9_1_6; -.
DR   InParanoid; P77808; -.
DR   OMA; PGVPYEM; -.
DR   PhylomeDB; P77808; -.
DR   BioCyc; EcoCyc:G7162-MON; -.
DR   PRO; PR:P77808; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   CDD; cd00885; cinA; 1.
DR   Gene3D; 3.40.980.10; -; 1.
DR   HAMAP; MF_00226_B; CinA_B; 1.
DR   InterPro; IPR036653; CinA-like_C.
DR   InterPro; IPR008135; Competence-induced_CinA.
DR   InterPro; IPR036425; MoaB/Mog-like_dom_sf.
DR   InterPro; IPR001453; MoaB/Mog_dom.
DR   Pfam; PF00994; MoCF_biosynth; 1.
DR   PIRSF; PIRSF006728; CinA; 1.
DR   SMART; SM00852; MoCF_biosynth; 1.
DR   SUPFAM; SSF142433; SSF142433; 1.
DR   SUPFAM; SSF53218; SSF53218; 1.
DR   TIGRFAMs; TIGR00200; cinA_nterm; 1.
DR   TIGRFAMs; TIGR00177; molyb_syn; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..400
FT                   /note="NMN amidohydrolase-like protein YfaY"
FT                   /id="PRO_0000156758"
SQ   SEQUENCE   400 AA;  44226 MW;  60A806AA4AB7D433 CRC64;
     MLKVEMLSTG DEVLHGQIVD TNAAWLADFF FHQGLPLSRR NTVGDNLDDL VTILRERSQH
     ADVLIVNGGL GPTSDDLSAL AAATAKGEGL VLHEAWLKEM ERYFHERGRV MAPSNRKQAE
     LPASAEFINN PVGTACGFAV QLNRCLMFFT PGVPSEFKVM VEHEILPRLR ERFSLPQPPV
     CLRLTTFGRS ESDLAQSLDT LQLPPGVTMG YRSSMPIIEL KLTGPASEQQ AMEKLWLDVK
     RVAGQSVIFE GTEGLPAQIS RELQNRQFSL TLSEQFTGGL LALQLSRAGA PLLACEVVPS
     QEETLAQTAH WITERRANHF AGLALAVSGF ENEHLNFALA TPDGTFALRV RFSTTRYSLA
     IRQEVCAMMA LNMLRRWLNG QDIASEHGWI EVVESMTLSV