ACH10_CHICK
ID ACH10_CHICK Reviewed; 452 AA.
AC Q9I8C7;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-10;
DE AltName: Full=Alpha 10 nAChR;
DE AltName: Full=Nicotinic acetylcholine receptor subunit alpha-10;
DE Short=NACHR alpha-10;
DE Flags: Precursor;
GN Name=CHRNA10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Spleen;
RA Barabino B., Boulter J., Alliod C., Ballivet M.;
RT "Alpha 10 nAChR expression in the developing chick embryo.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ionotropic receptor with a probable role in the modulation of
CC auditory stimuli. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the conotoxin GeXXA.
CC {ECO:0000250|UniProtKB:Q9JLB5}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; AJ295624; CAB99482.1; -; Genomic_DNA.
DR RefSeq; NP_001094506.1; NM_001101036.1.
DR AlphaFoldDB; Q9I8C7; -.
DR SMR; Q9I8C7; -.
DR ComplexPortal; CPX-225; Neuronal nicotinic acetylcholine receptor complex, alpha9-alpha10.
DR STRING; 9031.ENSGALP00000022064; -.
DR GeneID; 430628; -.
DR KEGG; gga:430628; -.
DR CTD; 57053; -.
DR VEuPathDB; HostDB:geneid_430628; -.
DR eggNOG; KOG3645; Eukaryota.
DR InParanoid; Q9I8C7; -.
DR OrthoDB; 845098at2759; -.
DR PhylomeDB; Q9I8C7; -.
DR PRO; PR:Q9I8C7; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IC:ComplexPortal.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051899; P:membrane depolarization; IDA:ComplexPortal.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 2.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Calcium; Calcium channel; Calcium transport; Cell membrane; Disulfide bond;
KW Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
KW Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
KW Synapse; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..452
FT /note="Neuronal acetylcholine receptor subunit alpha-10"
FT /id="PRO_0000000378"
FT TOPO_DOM 27..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT SITE 33
FT /note="Involved in the interaction with the conotoxin
FT GeXXA"
FT /evidence="ECO:0000250|UniProtKB:Q9JLB5"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 156..170
FT /evidence="ECO:0000250"
FT DISULFID 220..221
FT /note="Associated with receptor activation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 452 AA; 50052 MW; 3836C31530BAAAD8 CRC64;
MGSAPLPACL LALSLAGTVL APGCGAAQGR LAHKLLHDLF ANYSSALRPA EDTERALNVT
LQVTLSQIID MDERNQVLTS YLWVRQAWLD AHLAWDKDAY GGIDSIRIPS SYVWRPDIVL
YNNADERFGG SMETNVVLRS DGHIMWDSPA ITKSSCKVDV SYFPFDGQQC RLTFGSWTYN
GNQIDLRNLL DTGDLTDFVE NVEWEVLGMP ATRNVVTYGC CSEPYPDVTY TLLLRRRASF
YIFNLLLPCV MISFLAPLGF YLPADSGEKV SLGVTVLLAL TVFQLLVAES MPPSESVPLI
GKYYIATMTM ITASTALTIF IMNIHHCGPG ARPVPPWARR LILHHLARAL CVCEVGESCG
RPQREGTGGM GPRDPPGEGV EPGLCPRSRC LCHHHAVLSS VGYIAGVFRR HRTAQRRAAE
WKKVAKVMDR FFMWVFFLMV FLMSVLVIGK AA
