ID   CINA_STRP1              Reviewed;         423 AA.
AC   Q99XP1; Q48W57;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Putative competence-damage inducible protein {ECO:0000255|HAMAP-Rule:MF_00226};
GN   Name=cinA {ECO:0000255|HAMAP-Rule:MF_00226};
GN   OrderedLocusNames=SPy_2117, M5005_Spy1800;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SIMILARITY: Belongs to the CinA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00226}.
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DR   EMBL; AE004092; AAK34762.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ52418.1; -; Genomic_DNA.
DR   RefSeq; NP_270041.1; NC_002737.2.
DR   AlphaFoldDB; Q99XP1; -.
DR   SMR; Q99XP1; -.
DR   STRING; 1314.HKU360_01914; -.
DR   PaxDb; Q99XP1; -.
DR   EnsemblBacteria; AAK34762; AAK34762; SPy_2117.
DR   KEGG; spy:SPy_2117; -.
DR   KEGG; spz:M5005_Spy1800; -.
DR   PATRIC; fig|160490.10.peg.1834; -.
DR   HOGENOM; CLU_030805_9_3_9; -.
DR   OMA; PGVPYEM; -.
DR   Proteomes; UP000000750; Chromosome.
DR   CDD; cd00885; cinA; 1.
DR   Gene3D; 3.40.980.10; -; 1.
DR   Gene3D; 3.90.950.20; -; 1.
DR   HAMAP; MF_00226_B; CinA_B; 1.
DR   InterPro; IPR036653; CinA-like_C.
DR   InterPro; IPR008136; CinA_C.
DR   InterPro; IPR041424; CinA_KH.
DR   InterPro; IPR008135; Competence-induced_CinA.
DR   InterPro; IPR036425; MoaB/Mog-like_dom_sf.
DR   InterPro; IPR001453; MoaB/Mog_dom.
DR   Pfam; PF02464; CinA; 1.
DR   Pfam; PF18146; CinA_KH; 1.
DR   Pfam; PF00994; MoCF_biosynth; 1.
DR   PIRSF; PIRSF006728; CinA; 1.
DR   SMART; SM00852; MoCF_biosynth; 1.
DR   SUPFAM; SSF142433; SSF142433; 1.
DR   SUPFAM; SSF53218; SSF53218; 1.
DR   TIGRFAMs; TIGR00200; cinA_nterm; 1.
DR   TIGRFAMs; TIGR00177; molyb_syn; 1.
DR   TIGRFAMs; TIGR00199; PncC_domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..423
FT                   /note="Putative competence-damage inducible protein"
FT                   /id="PRO_0000156777"
SQ   SEQUENCE   423 AA;  45990 MW;  9F678341171005DB CRC64;
     MKAELIAVGT EILTGQIVNT NAQFLSEKMA ELGIDVYFQT AVGDNEERLL SVITTASQRS
     NLVILCGGLG PTKDDLTKQT LAKYLRKDLV YDEQACQKLD DFFAKRKPSS RTPNNERQAQ
     VIEGSIPLPN KTGLAVGGFI TVDGISYVVL PGPPSELKPM VNEELVPLLS KQYSTLYSKV
     LRFFGIGESQ LVTVLSDFIE NQTDPTIAPY AKTGEVTLRL STKTENQALA DKKLGQLEAQ
     LLSRKTLEGQ PLADVFYGYG EDNSLARETF ELLVKYDKTI TAAESLTAGL FQSTLASFPG
     ASQVFNGGFV TYSMEEKAKM LGLPLEELKS HGVVSAYTAE GMAEQARLLT GADIGVSLTG
     VAGPDMLEEQ PAGTVFIGLA TQNKVESIKV LISGRSRLDV RYIATLHAFN MVRKTLLKLE
     NLL