ID   CINA_STRPN              Reviewed;         418 AA.
AC   P54184; Q54853;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Putative competence-damage inducible protein;
DE   AltName: Full=Exported protein 10;
GN   Name=cinA; Synonyms=exp10; OrderedLocusNames=SP_1941;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R6 / R800;
RX   PubMed=7538190; DOI=10.1111/j.1365-2958.1995.tb02250.x;
RA   Martin B., Garcia P., Castanie M.-P., Claverys J.-P.;
RT   "The recA gene of Streptococcus pneumoniae is part of a competence-induced
RT   operon and controls lysogenic induction.";
RL   Mol. Microbiol. 15:367-379(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R6x;
RX   PubMed=7798154; DOI=10.1128/jb.177.1.86-93.1995;
RA   Pearce B.J., Naughton A.M., Campbell E.A., Masure H.R.;
RT   "The rec locus, a competence-induced operon in Streptococcus pneumoniae.";
RL   J. Bacteriol. 177:86-93(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- INDUCTION: By competence and damage.
CC   -!- SIMILARITY: Belongs to the CinA family. {ECO:0000305}.
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DR   EMBL; Z34303; CAA84071.1; -; Genomic_DNA.
DR   EMBL; L36131; AAC09382.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK76009.1; -; Genomic_DNA.
DR   PIR; D98091; D98091.
DR   PIR; H95226; H95226.
DR   RefSeq; WP_000642718.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P54184; -.
DR   SMR; P54184; -.
DR   STRING; 170187.SP_1941; -.
DR   EnsemblBacteria; AAK76009; AAK76009; SP_1941.
DR   KEGG; spn:SP_1941; -.
DR   eggNOG; COG1058; Bacteria.
DR   eggNOG; COG1546; Bacteria.
DR   OMA; PGVPYEM; -.
DR   PhylomeDB; P54184; -.
DR   BioCyc; SPNE170187:G1FZB-1996-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   CDD; cd00885; cinA; 1.
DR   Gene3D; 3.40.980.10; -; 1.
DR   Gene3D; 3.90.950.20; -; 1.
DR   HAMAP; MF_00226_B; CinA_B; 1.
DR   InterPro; IPR036653; CinA-like_C.
DR   InterPro; IPR008136; CinA_C.
DR   InterPro; IPR041424; CinA_KH.
DR   InterPro; IPR008135; Competence-induced_CinA.
DR   InterPro; IPR036425; MoaB/Mog-like_dom_sf.
DR   InterPro; IPR001453; MoaB/Mog_dom.
DR   Pfam; PF02464; CinA; 1.
DR   Pfam; PF18146; CinA_KH; 1.
DR   Pfam; PF00994; MoCF_biosynth; 1.
DR   PIRSF; PIRSF006728; CinA; 1.
DR   SMART; SM00852; MoCF_biosynth; 1.
DR   SUPFAM; SSF142433; SSF142433; 1.
DR   SUPFAM; SSF53218; SSF53218; 1.
DR   TIGRFAMs; TIGR00200; cinA_nterm; 1.
DR   TIGRFAMs; TIGR00199; PncC_domain; 1.
PE   2: Evidence at transcript level;
FT   CHAIN           1..418
FT                   /note="Putative competence-damage inducible protein"
FT                   /id="PRO_0000156743"
FT   CONFLICT        71
FT                   /note="P -> A (in Ref. 1; CAA84071 and 2; AAC09382)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        104
FT                   /note="T -> A (in Ref. 1; CAA84071 and 2; AAC09382)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        305
FT                   /note="K -> E (in Ref. 1; CAA84071 and 2; AAC09382)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        396
FT                   /note="R -> Q (in Ref. 2; AAC09382)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   418 AA;  45091 MW;  653F0ED282C48AB9 CRC64;
     MKAEIIAVGT EILTGQIVNT NAQFLSEKLA EIGVDVYFQT AVGDNEVRLL SLLEIASQRS
     SLVILTGGLG PTEDDLTKQT LAKFLGKALV FDPQAQEKLD IFFTLRPDYA RTPNNERQAQ
     IVEGAIPLPN ETGLAVGGKL EVDGVTYVVL PGPPSELKPM VLNQLLPKLM TGSKLYSRVL
     RFFGIGESQL VTILADLIDN QIDPTLAPYA KTGEVTLRLS TKASSQEEAN QALDILENQI
     LDCQTFEGIS LRDFCYGYGE ETSLASIVVE ELKRQGKTIA AAESLTAGLF QATVANFSGV
     SSIFKGGFVT YSLEEKSRML DIPAKNLEEH GVVSEFTAQK MAEQARSKTQ SDFGISLTGV
     AGPDSLEGHP VGTVFIGLAQ DQGTEVIKVN IGGRSRADVR HIAVMHAFNL VRKALLSD