ID   CINB_CITBR              Reviewed;         451 AA.
AC   Q8VQF5;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Cindoxin reductase;
DE            Short=CdR;
DE            EC=1.18.1.-;
DE   AltName: Full=NADPH-dependent flavodoxin/ferredoxin reductase {ECO:0000305};
DE   AltName: Full=NADPH-dependent flavodoxin/ferrodoxin reductase {ECO:0000303|PubMed:12016226};
GN   Name=cinB;
OS   Citrobacter braakii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter; Citrobacter freundii complex.
OX   NCBI_TaxID=57706;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=12016226; DOI=10.1074/jbc.m203382200;
RA   Hawkes D.B., Adams G.W., Burlingame A.L., Ortiz de Montellano P.R.,
RA   De Voss J.J.;
RT   "Cytochrome P450(cin) (CYP176A), isolation, expression, and
RT   characterization.";
RL   J. Biol. Chem. 277:27725-27732(2002).
CC   -!- FUNCTION: Involved in the degradation of cineol (eucalyptol). Catalyzes
CC       the reduction of cindoxin (CinC). {ECO:0000269|PubMed:12016226}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the ferredoxin--NADP reductase type 1 family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The authors of PubMed:12016226 consistently use the word
CC       ferrodoxin instead of ferredoxin. {ECO:0000305}.
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DR   EMBL; AF456128; AAL57615.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8VQF5; -.
DR   SMR; Q8VQF5; -.
DR   BioCyc; MetaCyc:MON-17203; -.
DR   GO; GO:0016731; F:oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor; IDA:UniProtKB.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR021163; Ferredox_Rdtase_adrenod.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PIRSF; PIRSF000362; FNR; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; NADP; Oxidoreductase; Transport.
FT   CHAIN           1..451
FT                   /note="Cindoxin reductase"
FT                   /id="PRO_0000422769"
FT   BINDING         24
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         45
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         53
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         89
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         157..160
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         197..198
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         338
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         345..347
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         345
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   451 AA;  49413 MW;  8403EA5D2F51E4D9 CRC64;
     MSKLQHHSIG EVEPSIAIVG SGPAGCYTAQ TLHKQWPSAQ IVIFERLPVP YGLLRYGVSP
     DHQGTKAIAR QFDRLFAEAS VHFIGNVEVG KHISVEELQD AFDVVVLAAG LGADRPLPSL
     AGDAVYGAGQ VMRWFNSHPD EQSFAPGFGA TTTIIGNGNV AMDVVRLLAK HRDSFTGSDL
     DPQLIEKQPS RIHVVGRSPA SAAKFDSMMI RELAEIDDAV FDVDVVDEPG HEDKRIHAKT
     KALLDLTAAR AVPSPRVHVS FHFGWTPESL EPTGDGRTLR LVNTESRLAV KLIETDSVIT
     AVGFGSGLRH EIDRVRFESA ASDLDNGLLD TGLYCSGWFR RGPTGGIPAN RLDAKMVCTR
     IIEDVASGAI TPKKRGLEEL ATHLHPDTVD FTGWQRIDAV EASRTEHGRC RTKLPDIATM
     LDFARNRTHE RTTDDTYRKQ ITDTVGHKEK R