ID   ACH1_SCHGR              Reviewed;         557 AA.
AC   P23414;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Acetylcholine receptor subunit alpha-L1;
DE   Flags: Precursor;
OS   Schistocerca gregaria (Desert locust) (Gryllus gregarius).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1702381; DOI=10.1002/j.1460-2075.1990.tb07889.x;
RA   Marshall J., Buckingham S.D., Shingai R., Lunt G.G., Goosey M.W.,
RA   Darlison M.G., Sattelle D.B., Barnard E.A.;
RT   "Sequence and functional expression of a single alpha subunit of an insect
RT   nicotinic acetylcholine receptor.";
RL   EMBO J. 9:4391-4398(1990).
CC   -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC       extensive change in conformation that affects all subunits and leads to
CC       opening of an ion-conducting channel across the plasma membrane.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC       protein. Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
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DR   EMBL; X55439; CAA39081.1; -; mRNA.
DR   PIR; S12359; S12359.
DR   AlphaFoldDB; P23414; -.
DR   SMR; P23414; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.58.390; -; 2.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW   Signal; Synapse; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..557
FT                   /note="Acetylcholine receptor subunit alpha-L1"
FT                   /id="PRO_0000000299"
FT   TOPO_DOM        24..244
FT                   /note="Extracellular"
FT   TRANSMEM        245..266
FT                   /note="Helical"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT   TRANSMEM        308..329
FT                   /note="Helical"
FT   TOPO_DOM        330..500
FT                   /note="Cytoplasmic"
FT   TRANSMEM        501..523
FT                   /note="Helical"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        235
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        151..165
FT                   /evidence="ECO:0000250"
FT   DISULFID        224..225
FT                   /note="Associated with receptor activation"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   557 AA;  63027 MW;  168389C887DFDF3E CRC64;
     MAAALPPMLL LLLLLLLHHP AAANPDAKRL YDDLLSNYNR LIRPVSNNTD TVLVKLGLRL
     SQLIDLNLKD QILTTNVWLE HEWQDHKFRW DPAEYGGVTE LYVPSEHIWL PDIVLYNNAD
     GEYVVTTMTK AVLHHTGKVV WTPPAIFKSS CEIDVRYFPF DQQTCFMKFG SWTYDGDQID
     LKHINQKYDD NKVKVGIDLR EYYPSVEWDI LGVPAERHEK YYPCCAEPYP DIFFNITLRR
     KTLFYTVNLI VPCVGISYLS VLVFYLPADS GEKIALCISI LLSQTMFFLL ISEIIPSTSL
     ALPLLGKYLL FTMVLVGLSV VITIMVLNVH YRKPSTHKMA PWVRKVFIRR LPKLLLMRVP
     EQLLADLASK RLLRHAHNSK LSAAAAAAVA AAASSSAASS PDSLRHHHLH QHQHQHHLQL
     HHLQRPGGCN GLHSATNRFG GSAGAFGGLP SVVGLDGSLS DVATRKKYPF ELEKAIHNVL
     FIQNHMQRQD EFDAEDQDWG FVAMVLDRLF LWIFTIASIV GTFAILCEAP ALYDDTKPID
     MELSSVAQQQ FLPDIDF