ID   CINP_BOVIN              Reviewed;         212 AA.
AC   A6H7E2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Cyclin-dependent kinase 2-interacting protein;
GN   Name=CINP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the DNA replication complex, which interacts
CC       with two kinases, CDK2 and CDC7, thereby providing a functional and
CC       physical link between CDK2 and CDC7 during firing of the origins of
CC       replication. Regulates ATR-mediated checkpoint signaling in response to
CC       DNA damage. Also involved in the cytoplasmic maturation steps of pre-
CC       60S ribosomal particles by promoting the release of shuttling protein
CC       RSL24D1/RLP24 from the pre-ribosomal particles. Promotes maturation of
CC       pre-60S ribosome together with SPATA5, SPATA5L1 and C1orf109.
CC       {ECO:0000250|UniProtKB:Q9BW66}.
CC   -!- SUBUNIT: Homodimer. Interacts with CDK2 and CDC7. Interacts with the
CC       components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6,
CC       MCM7 and with ORC2-containing complexes. Interacts with ATRIP.
CC       Interacts with CEP152. Associates with pre-60S ribosomal particles.
CC       Interacts with C1orf109 ortholog. {ECO:0000250|UniProtKB:Q9BW66}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW66}.
CC       Note=Binds to nuclear under G1 conditions, and dissociates from
CC       chromatin with the start of DNA replication.
CC       {ECO:0000250|UniProtKB:Q9BW66}.
CC   -!- PTM: Phosphorylated by CDC7 but not by CDK2.
CC       {ECO:0000250|UniProtKB:Q9BW66}.
CC   -!- SIMILARITY: Belongs to the CINP family. {ECO:0000305}.
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DR   EMBL; BC146212; AAI46213.1; -; mRNA.
DR   RefSeq; NP_001092595.1; NM_001099125.1.
DR   AlphaFoldDB; A6H7E2; -.
DR   STRING; 9913.ENSBTAP00000014592; -.
DR   PaxDb; A6H7E2; -.
DR   PRIDE; A6H7E2; -.
DR   Ensembl; ENSBTAT00000075752; ENSBTAP00000056909; ENSBTAG00000010995.
DR   GeneID; 613767; -.
DR   KEGG; bta:613767; -.
DR   CTD; 51550; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010995; -.
DR   VGNC; VGNC:27368; CINP.
DR   eggNOG; ENOG502S092; Eukaryota.
DR   GeneTree; ENSGT00390000015784; -.
DR   HOGENOM; CLU_077982_0_0_1; -.
DR   InParanoid; A6H7E2; -.
DR   OrthoDB; 1408353at2759; -.
DR   TreeFam; TF329462; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000010995; Expressed in oocyte and 105 other tissues.
DR   ExpressionAtlas; A6H7E2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990275; F:preribosome binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   InterPro; IPR023250; Cyclin-dep_Kinase_2_interact.
DR   PRINTS; PR02040; CDK2IP.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cell division; Coiled coil; DNA damage;
KW   DNA repair; DNA replication; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..212
FT                   /note="Cyclin-dependent kinase 2-interacting protein"
FT                   /id="PRO_0000326054"
FT   COILED          74..106
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BW66"
FT   MOD_RES         69
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BW66"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BW66"
SQ   SEQUENCE   212 AA;  24128 MW;  64234494C7FF638E CRC64;
     MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDGGFATANS IANMKISLSS
     KDKIELASSG LASNDCAEKE HPEYSRELET LCEELQATLE GLTKIQMKME KLSSTTKGVC
     ELEDYHHGEE RKRPPLFHTW PTAHFYEVSR KLSDMYSQEL RLKRTVVEQL AHTADRDLAL
     SYLSMWLHQP YLEAGSWLLL ESMLLETGHR VL