ID   CINP_XENLA              Reviewed;         207 AA.
AC   Q6GM07;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Cyclin-dependent kinase 2-interacting protein;
GN   Name=cinp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with the components of the replication complex (By
CC       similarity). Regulates checkpoint signaling (By similarity). Also
CC       involved in the cytoplasmic maturation steps of pre-60S ribosomal
CC       particles by promoting the release of shuttling protein RSL24D1/RLP24
CC       from the pre-ribosomal particles (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BW66}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW66}.
CC   -!- SIMILARITY: Belongs to the CINP family. {ECO:0000305}.
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DR   EMBL; BC074285; AAH74285.1; -; mRNA.
DR   RefSeq; NP_001086170.1; NM_001092701.1.
DR   AlphaFoldDB; Q6GM07; -.
DR   SMR; Q6GM07; -.
DR   DNASU; 444599; -.
DR   GeneID; 444599; -.
DR   KEGG; xla:444599; -.
DR   CTD; 444599; -.
DR   Xenbase; XB-GENE-954231; cinp.S.
DR   OrthoDB; 1408353at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 444599; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990275; F:preribosome binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   InterPro; IPR023250; Cyclin-dep_Kinase_2_interact.
DR   PRINTS; PR02040; CDK2IP.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; DNA damage; DNA repair;
KW   DNA replication; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..207
FT                   /note="Cyclin-dependent kinase 2-interacting protein"
FT                   /id="PRO_0000326057"
FT   COILED          78..99
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   207 AA;  23974 MW;  201A8417EF4ADD71 CRC64;
     MESKSPGYIT PKKPALSASA RKIKDNAADW HNLMLKWETY NNDSFNIASK IVNLKITAES
     ADRMLLDEPS PNKDNITTDK VELDRLCSEL LQTIENMEKI WTKMEKITAT FKGICDLEAY
     QFPGDTSKPT HFHTWPTTLF YETSMKMVDM YKKEIQLKRT IVGDLAHTSD QDLRMVYLSC
     WLYQPYIDNN IKVLLESMLL ETGHRPI