CIN_BPP1
ID CIN_BPP1 Reviewed; 186 AA.
AC P10311;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=DNA-invertase;
DE AltName: Full=Site-specific recombinase;
GN Name=cin;
OS Escherichia phage P1 (Bacteriophage P1).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Punavirus.
OX NCBI_TaxID=2886926;
OH NCBI_TaxID=543; Enterobacteriaceae.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6315399; DOI=10.1002/j.1460-2075.1983.tb01650.x;
RA Hiestand-Nauer R., Iida S.;
RT "Sequence of the site-specific recombinase gene cin and of its substrates
RT serving in the inversion of the C segment of bacteriophage P1.";
RL EMBO J. 2:1733-1740(1983).
RN [2]
RP SEQUENCE REVISION.
RA Iida S.;
RL Submitted (JUL-1987) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15489417; DOI=10.1128/jb.186.21.7032-7068.2004;
RA Lobocka M.B., Rose D.J., Plunkett G. III, Rusin M., Samojedny A.,
RA Lehnherr H., Yarmolinsky M.B., Blattner F.R.;
RT "Genome of bacteriophage P1.";
RL J. Bacteriol. 186:7032-7068(2004).
RN [4]
RP FUNCTION.
RX PubMed=6327269; DOI=10.1002/j.1460-2075.1982.tb01336.x;
RA Iida S., Meyer J., Kennedy K.E., Arber W.;
RT "A site-specific, conservative recombination system carried by
RT bacteriophage P1. Mapping the recombinase gene cin and the cross-over sites
RT cix for the inversion of the C segment.";
RL EMBO J. 1:1445-1453(1982).
CC -!- FUNCTION: Performs inversion of a viral 3 kp segment (C-segment) that
CC encodes two alternate pairs of tail fiber proteins thereby modifying
CC the host specificity of the virus. {ECO:0000269|PubMed:6327269}.
CC -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC {ECO:0000305}.
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DR EMBL; X01828; CAA25965.1; -; Genomic_DNA.
DR EMBL; AF234172; AAQ14003.1; -; Genomic_DNA.
DR PIR; S07175; S07175.
DR RefSeq; YP_006499.1; NC_005856.1.
DR SMR; P10311; -.
DR GeneID; 2777388; -.
DR KEGG; vg:2777388; -.
DR Proteomes; UP000008091; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0098678; P:viral tropism switching; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1390; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006118; Recombinase_CS.
DR InterPro; IPR006119; Resolv_N.
DR InterPro; IPR036162; Resolvase-like_N_sf.
DR InterPro; IPR006120; Resolvase_HTH_dom.
DR Pfam; PF02796; HTH_7; 1.
DR Pfam; PF00239; Resolvase; 1.
DR SMART; SM00857; Resolvase; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF53041; SSF53041; 1.
DR PROSITE; PS00397; RECOMBINASES_1; 1.
DR PROSITE; PS00398; RECOMBINASES_2; 1.
DR PROSITE; PS51736; RECOMBINASES_3; 1.
PE 3: Inferred from homology;
KW DNA integration; DNA invertase; DNA recombination; DNA-binding;
KW Reference proteome; Viral receptor tropism switching;
KW Virus entry into host cell.
FT CHAIN 1..186
FT /note="DNA-invertase"
FT /id="PRO_0000196356"
FT DOMAIN 1..134
FT /note="Resolvase/invertase-type recombinase catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
FT DNA_BIND 161..180
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
FT ACT_SITE 9
FT /note="O-(5'-phospho-DNA)-serine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
SQ SEQUENCE 186 AA; 21231 MW; 992B2D7CC13CFAD8 CRC64;
MLIGYVRVST NEQNTALQRN ALESAGCELI FEDKASGKKA ERPGLKKVLR MLSRGDTLVV
WKLDRLGRSM RHLVVLVEEL RDRGINFRSL TDSIDTSTPM GRFFFHVMGA LAEMERELIV
ERTRAGLDAA RAEGRIGGRR PKYQEETWQQ MRRLLEKGIP RKQVAIIYDV AVSTLYKKFP
ASSFQS
