ID   CIN_BPP7                Reviewed;         186 AA.
AC   P21703;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   29-SEP-2021, entry version 93.
DE   RecName: Full=DNA-invertase;
DE   AltName: Full=Site-specific recombinase;
GN   Name=cin;
OS   Enterobacteria phage P7 (Bacteriophage P7).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Punavirus.
OX   NCBI_TaxID=10682;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3399403; DOI=10.1093/nar/16.13.6246;
RA   Ritthaler W., Kamp D.;
RT   "DNA sequence of the site-specific recombination function cin of phage
RT   P7.";
RL   Nucleic Acids Res. 16:6246-6246(1988).
CC   -!- FUNCTION: Performs inversion of a viral 3 kp segment (C-segment) that
CC       encodes two alternate pairs of tail fiber proteins thereby modifying
CC       the host specificity of the virus. {ECO:0000250|UniProtKB:P10311}.
CC   -!- SIMILARITY: Belongs to the site-specific recombinase resolvase family.
CC       {ECO:0000305}.
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DR   EMBL; X07724; CAA30554.1; -; Genomic_DNA.
DR   PIR; S03663; JWBPP7.
DR   SMR; P21703; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0098678; P:viral tropism switching; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1390; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006118; Recombinase_CS.
DR   InterPro; IPR006119; Resolv_N.
DR   InterPro; IPR036162; Resolvase-like_N_sf.
DR   InterPro; IPR006120; Resolvase_HTH_dom.
DR   Pfam; PF02796; HTH_7; 1.
DR   Pfam; PF00239; Resolvase; 1.
DR   SMART; SM00857; Resolvase; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53041; SSF53041; 1.
DR   PROSITE; PS00397; RECOMBINASES_1; 1.
DR   PROSITE; PS00398; RECOMBINASES_2; 1.
DR   PROSITE; PS51736; RECOMBINASES_3; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA invertase; DNA recombination; DNA-binding;
KW   Viral receptor tropism switching; Virus entry into host cell.
FT   CHAIN           1..186
FT                   /note="DNA-invertase"
FT                   /id="PRO_0000196357"
FT   DOMAIN          1..134
FT                   /note="Resolvase/invertase-type recombinase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
FT   DNA_BIND        161..180
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        9
FT                   /note="O-(5'-phospho-DNA)-serine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01072"
SQ   SEQUENCE   186 AA;  21247 MW;  8D61C69D54F2C0ED CRC64;
     MLIGYVRVST NEQNTALQRN ALESAGCELI FEDKASGKQT ERPGLKKVLR MLSRGDTLVV
     WKLDRLGRSM RHLVVLVEEL RDRGINFRSL TDSIDTSTPM GRFFFHVMGA LAEMERELIV
     ERTRAGLDAA RAEGRIGGRR PKYQEETWQQ MRRLLENGIP RKQVAIIYDV AVSTLYKKFP
     ASSFQS