ID   CIPC_PONAB              Reviewed;         399 AA.
AC   Q5R8C5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=CLOCK-interacting pacemaker;
DE   AltName: Full=CLOCK-interacting circadian protein;
GN   Name=CIPC;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor which may act as a negative-
CC       feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the
CC       circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent
CC       phosphorylation of CLOCK. However, the physiogical relevance of these
CC       observations is unsure, since experiments in knockout mice showed that
CC       CIPC is not critially required for basic circadian clock.
CC       {ECO:0000250|UniProtKB:Q8R0W1}.
CC   -!- SUBUNIT: Interacts with CLOCK. Forms a ternary complex with the CLOCK-
CC       ARNTL/BMAL1 heterodimer (By similarity). Interacts with CAD AND HSPA5
CC       (By similarity). {ECO:0000250|UniProtKB:Q8R0W1,
CC       ECO:0000250|UniProtKB:Q9C0C6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R0W1}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9C0C6}. Note=Predominantly
CC       localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S
CC       boundary, partially translocated to the cytosol.
CC       {ECO:0000250|UniProtKB:Q8R0W1, ECO:0000250|UniProtKB:Q9C0C6}.
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DR   EMBL; CR859828; CAH91985.1; -; mRNA.
DR   RefSeq; NP_001126152.1; NM_001132680.1.
DR   AlphaFoldDB; Q5R8C5; -.
DR   SMR; Q5R8C5; -.
DR   STRING; 9601.ENSPPYP00000006843; -.
DR   GeneID; 100173111; -.
DR   KEGG; pon:100173111; -.
DR   CTD; 85457; -.
DR   eggNOG; ENOG502RJ2N; Eukaryota.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042754; P:negative regulation of circadian rhythm; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031602; CIPC.
DR   PANTHER; PTHR34648; PTHR34648; 1.
DR   Pfam; PF15800; CiPC; 1.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Coiled coil; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..399
FT                   /note="CLOCK-interacting pacemaker"
FT                   /id="PRO_0000256135"
FT   REGION          1..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          333..359
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         213
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9C0C6"
SQ   SEQUENCE   399 AA;  42739 MW;  34A0A54218D3321C CRC64;
     MERKNSSRES PRRLSAKVGK GTEMKKVARQ LGMAAAESDK DSGFSDGSSE CLSSAEQMES
     EDMLSALGWS REDRPRQNSK TAKNAFPTLS PMVVMKNVLV KQGSSSSQLQ SWTVQPSFEV
     ISAQPQLLFL HPPVPSPVSP CHTGEKKSDS RNYLPILNSY TKIAPHPGKR GLSVGPEEKG
     TSGVQKKICT ERLGPSLSSN EPTKAGAVPS SPSTPAPPSA KLAEDSALQG VPSLVAGGSP
     QTLQPVSSSH VAKAPSLTFA SPASPVCASD STLHGLESNS PLSPLSANYS SPLWAAEHLC
     RSPDIFSEQR QSKHRRFQNT LVVLHKSGLL EITLKTKELI RQNQATQVEL DQLKEQTQLF
     IEATKSRAPQ AWAKLQASLT PGSSNTGSDL EAFSDHPDI