ID   CIPC_XENLA              Reviewed;         346 AA.
AC   Q6NRH7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=CLOCK-interacting pacemaker;
DE   AltName: Full=CLOCK-interacting circadian protein;
GN   Name=cipc;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor which acts as a negative-feedback
CC       regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the
CC       circadian-clock mechanism. The physiogical relevance of these
CC       observations is unsure. {ECO:0000250|UniProtKB:Q8R0W1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R0W1}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9C0C6}. Note=Predominantly
CC       localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S
CC       boundary, partially translocated to the cytosol.
CC       {ECO:0000250|UniProtKB:Q8R0W1, ECO:0000250|UniProtKB:Q9C0C6}.
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DR   EMBL; BC070773; AAH70773.1; -; mRNA.
DR   RefSeq; NP_001084768.1; NM_001091299.1.
DR   AlphaFoldDB; Q6NRH7; -.
DR   SMR; Q6NRH7; -.
DR   DNASU; 431803; -.
DR   GeneID; 431803; -.
DR   KEGG; xla:431803; -.
DR   CTD; 431803; -.
DR   Xenbase; XB-GENE-6251780; cipc.S.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 431803; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042754; P:negative regulation of circadian rhythm; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031602; CIPC.
DR   PANTHER; PTHR34648; PTHR34648; 1.
DR   Pfam; PF15800; CiPC; 2.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Coiled coil; Cytoplasm; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..346
FT                   /note="CLOCK-interacting pacemaker"
FT                   /id="PRO_0000256136"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          283..315
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  38168 MW;  7ED68AD245FC2805 CRC64;
     MEKNQKCATE QERFKARSGH GDGQRAEPRK TQTTTESDKD SGYSDVASEC LSSVEQTDTE
     EGPTTSRWNV ALKPSGKTPS QPQSLVVLKN LLVDQGSGPE PNASSWAVHP SIQLLQTSPQ
     IVFFPPTVSS SKPSTCRKDT KYLPILKSYT KIAPHPSHRV SNISLPCARK RGPDERPHNQ
     TKRQCSKGHS GSRKGMDAAT LLDTGVQQGP VDQNVKESSV SAKNKELDMQ LTTQNINSNE
     KGSRVASLDT QQNLLSAGQQ NKSQRFQNTL DILHRSGLLS IAMKTKELAR HNQATQSQLE
     KLQEQVQLYA TAMSSNNPHD WQRLQDSLAE VVKGDTEDLS VREMDL