ID   CIR1_CHICK              Reviewed;         460 AA.
AC   Q5ZI03;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Corepressor interacting with RBPJ 1;
DE   AltName: Full=CBF1-interacting corepressor;
GN   Name=CIR1; Synonyms=CIR; ORFNames=RCJMB04_31l21;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May modulate splice site selection during alternative
CC       splicing of pre-mRNAs. Regulates transcription and acts as corepressor.
CC       Recruits repressors to the histone deacetylase complex (HDAC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}.
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DR   EMBL; AJ720981; CAG32640.1; -; mRNA.
DR   RefSeq; NP_001026557.1; NM_001031386.1.
DR   AlphaFoldDB; Q5ZI03; -.
DR   SMR; Q5ZI03; -.
DR   STRING; 9031.ENSGALP00000023047; -.
DR   PaxDb; Q5ZI03; -.
DR   PRIDE; Q5ZI03; -.
DR   Ensembl; ENSGALT00000023090; ENSGALP00000023047; ENSGALG00000014276.
DR   GeneID; 426529; -.
DR   KEGG; gga:426529; -.
DR   CTD; 9541; -.
DR   VEuPathDB; HostDB:geneid_426529; -.
DR   eggNOG; KOG3794; Eukaryota.
DR   GeneTree; ENSGT00730000111135; -.
DR   HOGENOM; CLU_035642_2_0_1; -.
DR   InParanoid; Q5ZI03; -.
DR   OMA; KGETEYK; -.
DR   OrthoDB; 1604301at2759; -.
DR   PhylomeDB; Q5ZI03; -.
DR   PRO; PR:Q5ZI03; -.
DR   Proteomes; UP000000539; Chromosome 7.
DR   Bgee; ENSGALG00000014276; Expressed in ovary and 13 other tissues.
DR   ExpressionAtlas; Q5ZI03; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR040014; CIR1.
DR   InterPro; IPR019339; CIR_N_dom.
DR   PANTHER; PTHR13151; PTHR13151; 1.
DR   Pfam; PF10197; Cir_N; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..460
FT                   /note="Corepressor interacting with RBPJ 1"
FT                   /id="PRO_0000247987"
FT   REGION          213..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           231..247
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           288..296
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        226..258
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..386
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..448
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  53378 MW;  F5095D8A1E088230 CRC64;
     MGKSFANFMC KKDFHPASKS NIKKVWMAEQ KISYDKKKQE ELMQQYLKEQ ESYDNRLLMG
     DERVKNGLNF MYEAPPGAKK EEAKEQEGET EYKFEWQKVA PREKYAKDDM NIRDQPFGIQ
     VRNVRCIKCH KWGHVNTDRE CPLFGLSGIN ASSVSSDGSG PSMHPSELIA EMRNSGFALK
     QNVLGRNLTA NDPSQEFVAS EGDDDPEVEF LKSLSTKQKQ KLLRKLDRLE KKKKKKDRKK
     KKQQKKKGKS KHKKHKMSSS SSSSSETSGS SSDSETDSRD KAAQKKMYSK KRKKGKFSEA
     SSSDSEGKAK TRKEKLYEDL SSSHGNKDKD REKYRLLKQD SSAENSKRSS CEGERKSKSR
     YQRETERKER DSRSQSADER RGRSPCTSHS SRRQRQTRKS PSQSPGEERH RKNETRSPST
     DGHRKEKKYR EGNGDRCSNV EYRERSRRSR SRSRERKKKR