CIS1_YEAST
ID CIS1_YEAST Reviewed; 101 AA.
AC Q06139; D6VYY5;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Citrinin resistance protein, mitochondrial {ECO:0000303|PubMed:26713447};
DE AltName: Full=Citrinin sensitive knockout protein 1 {ECO:0000303|PubMed:26713447};
GN Name=CIS1 {ECO:0000303|PubMed:26713447}; OrderedLocusNames=YLR346C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INDUCTION.
RX PubMed=11470516; DOI=10.1016/s0378-1119(01)00558-3;
RA do Valle Matta M.A., Jonniaux J.-L., Balzi E., Goffeau A.,
RA van den Hazel B.;
RT "Novel target genes of the yeast regulator Pdr1p: a contribution of the
RT TPO1 gene in resistance to quinidine and other drugs.";
RL Gene 272:111-119(2001).
RN [5]
RP INDUCTION.
RX PubMed=11909958; DOI=10.1128/mcb.22.8.2642-2649.2002;
RA Le Crom S., Devaux F., Marc P., Zhang X., Moye-Rowley W.S., Jacq C.;
RT "New insights into the pleiotropic drug resistance network from genome-wide
RT characterization of the YRR1 transcription factor regulation system.";
RL Mol. Cell. Biol. 22:2642-2649(2002).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP FUNCTION, AND INDUCTION.
RX PubMed=26713447; DOI=10.1371/journal.pgen.1005751;
RA Naranjo S., Smith J.D., Artieri C.G., Zhang M., Zhou Y., Palmer M.E.,
RA Fraser H.B.;
RT "Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.";
RL PLoS Genet. 11:E1005751-E1005751(2015).
CC -!- FUNCTION: Mitochondrial protein that is involved in citrinin
CC resistance. {ECO:0000269|PubMed:26713447}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- INDUCTION: Expression is induced in the presence of citrinin
CC (PubMed:26713447). Expression is induced by the PDR1 and YRR1 multidrug
CC resistance transcription factors (PubMed:11470516, PubMed:11909958).
CC {ECO:0000269|PubMed:11470516, ECO:0000269|PubMed:11909958,
CC ECO:0000269|PubMed:26713447}.
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DR EMBL; U19028; AAB67264.1; -; Genomic_DNA.
DR EMBL; AY692581; AAT92600.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09651.1; -; Genomic_DNA.
DR PIR; S51349; S51349.
DR RefSeq; NP_013450.1; NM_001182235.1.
DR AlphaFoldDB; Q06139; -.
DR BioGRID; 31609; 119.
DR DIP; DIP-5578N; -.
DR IntAct; Q06139; 2.
DR STRING; 4932.YLR346C; -.
DR iPTMnet; Q06139; -.
DR PaxDb; Q06139; -.
DR EnsemblFungi; YLR346C_mRNA; YLR346C; YLR346C.
DR GeneID; 851060; -.
DR KEGG; sce:YLR346C; -.
DR SGD; S000004338; CIS1.
DR VEuPathDB; FungiDB:YLR346C; -.
DR HOGENOM; CLU_2307651_0_0_1; -.
DR OMA; MQSISNC; -.
DR BioCyc; YEAST:G3O-32422-MON; -.
DR PRO; PR:Q06139; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06139; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..101
FT /note="Citrinin resistance protein, mitochondrial"
FT /id="PRO_0000247212"
SQ SEQUENCE 101 AA; 11348 MW; 0662D0D991616587 CRC64;
MQSISNCPIG LVSKNTINSA STIAEWVACP WKYINVVGSG RYVSNKPDKI TRYDLLKAAQ
EAEMQELLTR NDMKGRHKRN KKSKIALETI AEENSSTESL F
