CISD2_DROPE
ID CISD2_DROPE Reviewed; 132 AA.
AC B4GPI0;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=CDGSH iron-sulfur domain-containing protein 2 homolog;
GN Name=Cisd2 {ECO:0000250|UniProtKB:Q9VAM6}; ORFNames=GL13882;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily.
CC {ECO:0000305}.
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DR EMBL; CH479186; EDW39063.1; -; Genomic_DNA.
DR RefSeq; XP_002020251.1; XM_002020215.1.
DR AlphaFoldDB; B4GPI0; -.
DR SMR; B4GPI0; -.
DR STRING; 7234.FBpp0177989; -.
DR EnsemblMetazoa; FBtr0179497; FBpp0177989; FBgn0151487.
DR GeneID; 6594848; -.
DR KEGG; dpe:6594848; -.
DR eggNOG; KOG3461; Eukaryota.
DR HOGENOM; CLU_132293_1_0_1; -.
DR OMA; VVDMIDI; -.
DR PhylomeDB; B4GPI0; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007568; P:aging; IEA:EnsemblMetazoa.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0006839; P:mitochondrial transport; IEA:EnsemblMetazoa.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR Gene3D; 3.40.5.90; -; 1.
DR InterPro; IPR045131; CISD1/2.
DR InterPro; IPR018967; FeS-contain_CDGSH-typ.
DR InterPro; IPR019610; FeS-contain_mitoNEET_N.
DR InterPro; IPR042216; MitoNEET_CISD.
DR PANTHER; PTHR13680; PTHR13680; 1.
DR Pfam; PF10660; MitoNEET_N; 1.
DR Pfam; PF09360; zf-CDGSH; 1.
DR SMART; SM00704; ZnF_CDGSH; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Endoplasmic reticulum; Iron; Iron-sulfur; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..132
FT /note="CDGSH iron-sulfur domain-containing protein 2
FT homolog"
FT /id="PRO_0000392027"
FT TOPO_DOM 1..35
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT BINDING 98
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 100
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 109
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 113
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
SQ SEQUENCE 132 AA; 14407 MW; 0AE1A356B5E79A73 CRC64;
MEPISHVVKS SLPNYLSSLP IPDSFGGWFK LSFKDWLALI PPTVVVAGLG YTTYLAFCPA
ARCAGKDSGR CNSSIRKNEA KVVTMVDVED IAGQAAFCRC WKTKNWPYCD GSHGEHNKQT
GDNVGPVVVK KK
